|
rs104893891
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient.
|
8896568 |
1996 |
|
rs104893891
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease.
|
8968758 |
1996 |
|
rs104893891
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease.
|
8896569 |
1996 |
|
rs104893891
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
Pathogenesis of Hirschsprung's disease.
|
10917288 |
2000 |
|
rs104893891
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
A |
0.800 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs1110149
|
GDNF;GDNF-AS1
|
Tinnitus
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity was significantly lower for GDNF rs1110149 polymorphism in tinnitus subjects compared to the controls (p < 0.05).
|
27180191 |
2016 |
|
rs11111
|
GDNF;GDNF-AS1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs11111
|
GDNF;GDNF-AS1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs11111
|
GDNF;GDNF-AS1
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs11111
|
GDNF;GDNF-AS1
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs11111
|
GDNF;GDNF-AS1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs11747340
|
GDNF;GDNF-AS1
|
Blood Protein Measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.
|
31320639 |
2019 |
|
rs121918536
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease.
|
8896569 |
1996 |
|
rs121918536
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
C |
0.800 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs121918536
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient.
|
8896568 |
1996 |
|
rs121918536
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
Pathogenesis of Hirschsprung's disease.
|
10917288 |
2000 |
|
rs121918536
|
GDNF;GDNF-AS1
|
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3
|
|
0.800 |
GeneticVariation |
UNIPROT |
De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease.
|
8968758 |
1996 |
|
rs1227230819
|
GDNF;GDNF-AS1
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-base substitution was found in exon 1 (227G>A) of the XBP1 gene in a patient with diffuse large B-cell lymphoma, resulting in a somatic missense mutation (R76K).
|
19380033 |
2009 |
|
rs1227230819
|
GDNF;GDNF-AS1
|
Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-base substitution was found in exon 1 (227G>A) of the XBP1 gene in a patient with diffuse large B-cell lymphoma, resulting in a somatic missense mutation (R76K).
|
19380033 |
2009 |
|
rs2973050
|
GDNF;GDNF-AS1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs2973050
|
GDNF;GDNF-AS1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
Results of the allele-wise single marker association analyses provided significant effects of two single nucleotide polymorphisms on anxiety scores following the Bonferroni correction for multiple testing (p = 0.00070 and p = 0.00138 for rs3812047 and rs3096140, respectively), while no such result was obtained on depression scores.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
Results of the allele-wise single marker association analyses provided significant effects of two single nucleotide polymorphisms on anxiety scores following the Bonferroni correction for multiple testing (p = 0.00070 and p = 0.00138 for rs3812047 and rs3096140, respectively), while no such result was obtained on depression scores.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, this is the first demonstration of a significant association between the GDNF gene and mood characteristics demonstrated by the association of two SNPs of the GDNF gene (rs3812047 and rs3096140) and individual variability of anxiety using self-report data from a non-clinical sample.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, this is the first demonstration of a significant association between the GDNF gene and mood characteristics demonstrated by the association of two SNPs of the GDNF gene (rs3812047 and rs3096140) and individual variability of anxiety using self-report data from a non-clinical sample.
|
24324616 |
2013 |