GNAS, GNAS complex locus, 2778

N. diseases: 536; N. variants: 61
Disease: Growth Hormone-Secreting Pituitary Adenoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1290398674
rs1290398674
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
CUI: C0346302
Disease:
Growth Hormone-Secreting Pituitary Adenoma 		0.010 GeneticVariation BEFREE Given that both adrenocortical adenomas and somatotroph adenomas are known to be reliant on the cAMP signalling pathway, we sought to determine the relevance of the L206R mutation in both PRKACA and PRKACB for the pathogenesis of sporadic somatotroph adenomas. 25225481 2014