|
rs217727
|
MRPL23;H19;HOTS
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
The T allele of rs2839698 conferred breas</span>t cancer risk in the assessed population (OR (95% CI) = 2.52 (1.75-3.64), adjusted P value = 1.3E-6), while and the T allele of rs217727 had a protective effect (OR (95% CI) = 0.42 (0.27-0.66), adjusted P value = 2.8E-4).
|
30910558 |
2019 |
|
rs217727
|
MRPL23;H19;HOTS
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
Our findings suggested that rs217727 C>T polymorphism may be involved in the pathogenesis of BC, whereas rs3741219 T>C variation may not be involved in the genetic background of BC in Iranian.
|
30485527 |
2019 |
|
rs217727
|
MRPL23;H19;HOTS
|
Breast Carcinoma
|
A |
0.740 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
Subsequent stratified analyses also revealed that associations between BC risk and rs217727 genotypes were more profound in patients with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, and hormone receptor-positive-HER2-negative molecular subtypes (all passed the threshold for Bonferroni correction, <i>P</i><0.005).
|
28919786 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
However, in further stratified analyses, CT+TT genotypes of rs217727 had a significantly lower risk of breast cancer among women with number of pregnancy >2 (OR = 0.79; 95% CI = 0.55-0.97).
|
26886624 |
2016 |
|
rs217727
|
MRPL23;H19;HOTS
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
rs217727
|
MRPL23;H19;HOTS
|
Systolic Pressure
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
rs217727
|
MRPL23;H19;HOTS
|
Systolic Pressure
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis revealed H19 rs217727 may influence cancer susceptibility.
|
31752724 |
2019 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis revealed H19 rs217727 may influence cancer susceptibility.
|
31752724 |
2019 |
|
rs217727
|
MRPL23;H19;HOTS
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk.
|
28404885 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation |
BEFREE |
In the lncRNA H19, the rs2735971 A/G, rs2839698C/T, and rs3024270 G/C polymorphisms, but not rs217727C/T, were correlated with overall cancer risk.
|
28342449 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation |
BEFREE |
No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk.
|
28404885 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
In the lncRNA H19, the rs2735971 A/G, rs2839698C/T, and rs3024270 G/C polymorphisms, but not rs217727C/T, were correlated with overall cancer risk.
|
28342449 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
Overall, no significant association was observed between the rs217727 polymorphism and cancer susceptibility in any of the four genetic models.
|
27486980 |
2016 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation |
BEFREE |
Overall, no significant association was observed between the rs217727 polymorphism and cancer susceptibility in any of the four genetic models.
|
27486980 |
2016 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation |
BEFREE |
Thus, we performed a meta-analysis to estimate the associations between H19 polymorphisms (rs2107425, rs2839698 and rs217727) and cancer risk.
|
27732938 |
2016 |
|
rs217727
|
MRPL23;H19;HOTS
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
Thus, we performed a meta-analysis to estimate the associations between H19 polymorphisms (rs2107425, rs2839698 and rs217727) and cancer risk.
|
27732938 |
2016 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
The T allele of rs2839698 conferred breas</span>t cancer risk in the assessed population (OR (95% CI) = 2.52 (1.75-3.64), adjusted P value = 1.3E-6), while and the T allele of rs217727 had a protective effect (OR (95% CI) = 0.42 (0.27-0.66), adjusted P value = 2.8E-4).
|
30910558 |
2019 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
Our findings suggested that rs217727 C>T polymorphism may be involved in the pathogenesis of BC, whereas rs3741219 T>C variation may not be involved in the genetic background of BC in Iranian.
|
30485527 |
2019 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
Subsequent stratified analyses also revealed that associations between BC risk and rs217727 genotypes were more profound in patients with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, and hormone receptor-positive-HER2-negative molecular subtypes (all passed the threshold for Bonferroni correction, <i>P</i><0.005).
|
28919786 |
2017 |
|
rs217727
|
MRPL23;H19;HOTS
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation |
BEFREE |
However, in further stratified analyses, CT+TT genotypes of rs217727 had a significantly lower risk of breast cancer among women with number of pregnancy >2 (OR = 0.79; 95% CI = 0.55-0.97).
|
26886624 |
2016 |
|
rs2107425
|
MRPL23;H19
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation |
BEFREE |
Moreover, a protective effect against cance</span>r development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations.
|
28404885 |
2017 |
|
rs2107425
|
MRPL23;H19
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation |
BEFREE |
However, we did not observe any significant association between H19 rs2107425 and cancer risk.
|
28159929 |
2017 |
|
rs2107425
|
MRPL23;H19
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation |
BEFREE |
Moreover, a protective effect against cance</span>r development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations.
|
28404885 |
2017 |