DisGeNET - a database of gene-disease associations

HECTD4, HECT domain E3 ubiquitin protein ligase 4, 283450

N. diseases: 19; N. variants: 5

Source: GWASDB ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.810

GeneticVariation

GWASDB

New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.

23575436

2013

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0013124
Disease:

Drinking behavior processes

0.800

GeneticVariation

GWASDB

The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P < 5 × 10(-8)), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 × 10(-215)).

23364009

2013

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0010068
Disease:

Coronary heart disease

0.800

GeneticVariation

GWASDB

A genome-wide association study of a coronary artery disease risk variant.

23364394

2013

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0001948
Disease:

Alcohol consumption

0.800

GeneticVariation

GWASDB

Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

23555315

2013

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0010068
Disease:

Coronary heart disease

0.800

GeneticVariation

GWASDB

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

22751097

2012

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0010068
Disease:

Coronary heart disease

0.800

GeneticVariation

GWASDB

Genome-wide association study of coronary artery disease in the Japanese.

21971053

2012

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0005845
Disease:

Blood urea nitrogen measurement

0.800

GeneticVariation

GWASDB

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

22797727

2012

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0392885
Disease:

High density lipoprotein measurement

0.800

GeneticVariation

GWASDB

Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

21909109

2011

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0001948
Disease:

Alcohol consumption

0.800

GeneticVariation

GWASDB

Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.

21270382

2011

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0014859
Disease:

Esophageal Neoplasms

0.800

GeneticVariation

GWASDB

Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.

20833657

2010

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0014859
Disease:

Esophageal Neoplasms

0.800

GeneticVariation

GWASDB

Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.

20833657

2010

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0205682
Disease:

Waist-Hip Ratio

0.800

GeneticVariation

GWASDB

For waist-hip ratio, variants on chromosome 12q24 (rs2074356, P = 7.8 x 10(-12)) showed convincing associations, although no regional transcript has strong biological candidacy.

19396169

2009

dbSNP:

rs11066188

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0039685
Disease:

Tetralogy of Fallot

0.700

GeneticVariation

GWASDB

Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.

23297363

2013

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C1269683
Disease:

Major Depressive Disorder

0.700

GeneticVariation

GWASDB

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.

23377640

2013

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0001948
Disease:

Alcohol consumption

0.700

GeneticVariation

GWASDB

Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

23555315

2013

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C1269683
Disease:

Major Depressive Disorder

0.700

GeneticVariation

GWASDB

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.

23377640

2013

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0010068
Disease:

Coronary heart disease

0.700

GeneticVariation

GWASDB

A genome-wide association study of a coronary artery disease risk variant.

23364394

2013

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0013124
Disease:

Drinking behavior processes

0.700

GeneticVariation

GWASDB

Common variants at 12q24 are associated with drinking behavior in Han Chinese.

23364009

2013

dbSNP:

rs77768175

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0010068
Disease:

Coronary heart disease

0.700

GeneticVariation

GWASDB

A genome-wide association study of a coronary artery disease risk variant.

23364394

2013

dbSNP:

rs11066188

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0020676
Disease:

Hypothyroidism

0.700

GeneticVariation

GWASDB

Novel associations for hypothyroidism include known autoimmune risk loci.

22493691

2012

dbSNP:

rs11066188

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C4528257
Disease:

Corpuscular Hemoglobin Concentration Mean

0.700

GeneticVariation

GWASDB

Seventy-five genetic loci influencing the human red blood cell.

23222517

2012

dbSNP:

rs2074356

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0010068
Disease:

Coronary heart disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of coronary artery disease in the Japanese.

21971053

2012

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0546837
Disease:

Malignant neoplasm of esophagus

0.700

GeneticVariation

GWASDB

Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

21642993

2011

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0005823
Disease:

Blood Pressure

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

21572416

2011

dbSNP:

rs11066280

Entrez Id:	283450
Gene Symbol:	HECTD4

HECTD4

CUI:	C0523465
Disease:

Serum albumin measurement

0.700

GeneticVariation

GWASDB

Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

21909109

2011