|
rs3802141
|
GPER1;C7orf50
|
Endometriosis of uterus
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs3802141 CT genotype was more common in the control group (p = .02), and the rs4266553 CC genotype was more common in the adenomyosis group (p = .02).
|
30626229 |
2019 |
|
rs4266553
|
GPER1;C7orf50
|
Endometriosis of uterus
|
|
0.010 |
GeneticVariation |
BEFREE |
The C allele of the SNP rs4266553 was more common in the adenomyosis group (p = .02).
|
30626229 |
2019 |
|
rs11544331
|
GPER1;C7orf50
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Surveying a small set of CAFs from breast cancer</span> biopsies, we found that a relatively common single nucleotide polymorphism, which results in the expression of a GPER variant with the amino acid substitution P16L, is associated with the nuclear localization of GPER.
|
28596490 |
2017 |
|
rs11544331
|
GPER1;C7orf50
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Surveying a small set of CAFs from breast cancer</span> biopsies, we found that a relatively common single nucleotide polymorphism, which results in the expression of a GPER variant with the amino acid substitution P16L, is associated with the nuclear localization of GPER.
|
28596490 |
2017 |
|
rs3808350
|
GPER1;C7orf50
|
Fibroid Tumor
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs3808351 and the GG genotype of both the rs3808350 and rs3808351 polymorphisms and the GGC haplotype increased the risk of developing leiomyoma.
|
26773178 |
2016 |
|
rs3808350
|
GPER1;C7orf50
|
Uterine Fibroids
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs3808351 and the GG genotype of both the rs3808350 and rs3808351 polymorphisms and the GGC haplotype increased the risk of developing leiomyoma.
|
26773178 |
2016 |
|
rs3808351
|
GPER1;C7orf50
|
Solitary leiomyoma
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the GG genotype of the GPR30 rs3808351 polymorphism and G allele of the GPR30 rs3808351 polymorphism were associated with the risk of having a single leiomyoma.
|
26773178 |
2016 |
|
rs3808351
|
GPER1;C7orf50
|
Uterine Fibroids
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs3808351 and the GG genotype of both the rs3808350 and rs3808351 polymorphisms and the GGC haplotype increased the risk of developing leiomyoma.
|
26773178 |
2016 |
|
rs3808351
|
GPER1;C7orf50
|
Fibroid Tumor
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs3808351 and the GG genotype of both the rs3808350 and rs3808351 polymorphisms and the GGC haplotype increased the risk of developing leiomyoma.
|
26773178 |
2016 |
|
rs3808350
|
GPER1;C7orf50
|
Gynecomastia
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that increased E2 levels, the G allele of rs3808350 and the A allele of rs3808351 might explain why certain adolescents are affected by gynecomastia.
|
25531203 |
2015 |
|
rs3808351
|
GPER1;C7orf50
|
Gynecomastia
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that increased E2 levels, the G allele of rs3808350 and the A allele of rs3808351 might explain why certain adolescents are affected by gynecomastia.
|
25531203 |
2015 |
|
rs11544331
|
GPER1;C7orf50
|
Hypertensive disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The common genetic variant, GPER P16L, is hypofunctional and female carriers of this allele have increased blood pressure.
|
25039431 |
2014 |
|
rs3808350
|
GPER1;C7orf50
|
Seminoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared to control population, loss of homozygous ancestral genotype GG in two polymorphisms located in the promoter region of GPER (rs3808350 and rs3808351) was more frequent in seminomas but not in non-seminomas (respectively, OR = 1.960 (1.172-3.277) and 7.000 (2.747-17.840); p < 0.01).
|
24451139 |
2014 |
|
rs3808351
|
GPER1;C7orf50
|
Seminoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared to control population, loss of homozygous ancestral genotype GG in two polymorphisms located in the promoter region of GPER (rs3808350 and rs3808351) was more frequent in seminomas but not in non-seminomas (respectively, OR = 1.960 (1.172-3.277) and 7.000 (2.747-17.840); p < 0.01).
|
24451139 |
2014 |
|
rs10269151
|
GPER1;C7orf50
|
Androgen-Insensitivity Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
However, heterozygotes in three SNPs of the gene (rs3808351, rs10269151 and rs426655s3) were related significantly with the curve severity in AIS patients (P = 0.004, 0.048 and 0.028, respectively).
|
22002330 |
2012 |
|
rs3808351
|
GPER1;C7orf50
|
Androgen-Insensitivity Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
However, heterozygotes in three SNPs of the gene (rs3808351, rs10269151 and rs426655s3) were related significantly with the curve severity in AIS patients (P = 0.004, 0.048 and 0.028, respectively).
|
22002330 |
2012 |
|
rs11544331
|
GPER1;C7orf50
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Both homozygous GG genotype of promoter SNP rs3808350 and T allele of missense SNP rs11544331 were inversely associated with PR-negativity, suggesting that they might exert protective effects regarding development of PR-negative cancer.
|
19744559 |
2010 |
|
rs11544331
|
GPER1;C7orf50
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Both homozygous GG genotype of promoter SNP rs3808350 and T allele of missense SNP rs11544331 were inversely associated with PR-negativity, suggesting that they might exert protective effects regarding development of PR-negative cancer.
|
19744559 |
2010 |
|
rs3808350
|
GPER1;C7orf50
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Both homozygous GG genotype of promoter SNP rs3808350 and T allele of missense SNP rs11544331 were inversely associated with PR-negativity, suggesting that they might exert protective effects regarding development of PR-negative cancer.
|
19744559 |
2010 |
|
rs3808350
|
GPER1;C7orf50
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Both homozygous GG genotype of promoter SNP rs3808350 and T allele of missense SNP rs11544331 were inversely associated with PR-negativity, suggesting that they might exert protective effects regarding development of PR-negative cancer.
|
19744559 |
2010 |
|
rs3808351
|
GPER1;C7orf50
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of SNP rs3808351 was significantly less frequent in patients with large or G3 tumors, T allele of SNP rs11544331 less frequently occurred in patients with positive nodal status, suggesting that both SNPs might exert protective effects regarding aggressive breast cancer entities.
|
19744559 |
2010 |