GRN, granulin precursor, 2896

N. diseases: 412; N. variants: 66
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs63751243
rs63751243
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		0.800 GeneticVariation UNIPROT
dbSNP: rs63751243
rs63751243
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		A 0.800 CausalMutation CLINVAR
dbSNP: rs1392550887
rs1392550887
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C3539123
Disease:
CEROID LIPOFUSCINOSIS, NEURONAL, 11 		GC 0.700 CausalMutation CLINVAR
dbSNP: rs1392550887
rs1392550887
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		GC 0.700 CausalMutation CLINVAR
dbSNP: rs1555611256
rs1555611256
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		C 0.700 CausalMutation CLINVAR
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		G 0.700 CausalMutation CLINVAR Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage. 22608501 2012
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C3539123
Disease:
CEROID LIPOFUSCINOSIS, NEURONAL, 11 		G 0.700 CausalMutation CLINVAR Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. 16950801 2006
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C3539123
Disease:
CEROID LIPOFUSCINOSIS, NEURONAL, 11 		G 0.700 CausalMutation CLINVAR Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. 21482928 2011
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C3539123
Disease:
CEROID LIPOFUSCINOSIS, NEURONAL, 11 		G 0.700 CausalMutation CLINVAR The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. 20142524 2010
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C3539123
Disease:
CEROID LIPOFUSCINOSIS, NEURONAL, 11 		G 0.700 CausalMutation CLINVAR Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage. 22608501 2012
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		G 0.700 CausalMutation CLINVAR The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. 20142524 2010
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C3539123
Disease:
CEROID LIPOFUSCINOSIS, NEURONAL, 11 		G 0.700 CausalMutation CLINVAR Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. 16862116 2006
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		G 0.700 CausalMutation CLINVAR Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. 16950801 2006
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		G 0.700 CausalMutation CLINVAR Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. 21482928 2011
dbSNP: rs1555611412
rs1555611412
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		G 0.700 CausalMutation CLINVAR Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. 16862116 2006
dbSNP: rs1567885658
rs1567885658
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0338451
Disease:
Frontotemporal dementia 		CT 0.700 CausalMutation CLINVAR
dbSNP: rs1567885728
rs1567885728
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease:
Alzheimer's Disease 		A 0.700 GeneticVariation CLINVAR
dbSNP: rs1567886206
rs1567886206
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0338451
Disease:
Frontotemporal dementia 		TA 0.700 CausalMutation CLINVAR
dbSNP: rs1567886445
rs1567886445
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0338451
Disease:
Frontotemporal dementia 		TTGTGAAGACAGGGTGCACTGCTGTC 0.700 CausalMutation CLINVAR
dbSNP: rs1567886478
rs1567886478
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0338451
Disease:
Frontotemporal dementia 		C 0.700 CausalMutation CLINVAR
dbSNP: rs1567887015
rs1567887015
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0338451
Disease:
Frontotemporal dementia 		TA 0.700 CausalMutation CLINVAR
dbSNP: rs1567887496
rs1567887496
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C1843792
Disease:
FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED 		T 0.700 CausalMutation CLINVAR
dbSNP: rs1567887496
rs1567887496
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C3539123
Disease:
CEROID LIPOFUSCINOSIS, NEURONAL, 11 		T 0.700 CausalMutation CLINVAR
dbSNP: rs1567887777
rs1567887777
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0338451
Disease:
Frontotemporal dementia 		A 0.700 GeneticVariation CLINVAR
dbSNP: rs1567888461
rs1567888461
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0338451
Disease:
Frontotemporal dementia 		A 0.700 CausalMutation CLINVAR