GRM4, glutamate metabotropic receptor 4, 2914

N. diseases: 54; N. variants: 5
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0029463
Disease:
Osteosarcoma
0.820 GeneticVariation BEFREE Survival analysis for rs1906953 showed that the median survival time of osteosarcoma patients with the CC genotype was significantly shorter compared to the CT and TT genotypes; patients carrying CC genotype have apparently got a decrease in their recurrence-free survival time in comparison with patients carrying TT genotype. 26276359 2016
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0029463
Disease:
Osteosarcoma
0.820 GeneticVariation BEFREE Further analysis showed the association between rs1906953 and OS was independent of gender and age. 24984297 2014
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0029463
Disease:
Osteosarcoma
A 0.820 GeneticVariation GWASCAT Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862 2013
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0029463
Disease:
Osteosarcoma
A 0.820 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862 2013
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C1332986
Disease:
Childhood Osteosarcoma
0.020 GeneticVariation BEFREE Survival analysis for rs1906953 showed that the median survival time of osteosarcoma patients with the CC genotype was significantly shorter compared to the CT and TT genotypes; patients carrying CC genotype have apparently got a decrease in their recurrence-free survival time in comparison with patients carrying TT genotype. 26276359 2016
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0585442
Disease:
Osteosarcoma of bone
0.020 GeneticVariation BEFREE Survival analysis for rs1906953 showed that the median survival time of osteosarcoma patients with the CC genotype was significantly shorter compared to the CT and TT genotypes; patients carrying CC genotype have apparently got a decrease in their recurrence-free survival time in comparison with patients carrying TT genotype. 26276359 2016
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C1332986
Disease:
Childhood Osteosarcoma
0.020 GeneticVariation BEFREE Further analysis showed the association between rs1906953 and OS was independent of gender and age. 24984297 2014
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0585442
Disease:
Osteosarcoma of bone
0.020 GeneticVariation BEFREE Further analysis showed the association between rs1906953 and OS was independent of gender and age. 24984297 2014
dbSNP: rs2499697
rs2499697
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0014548
Disease:
Epilepsy, Generalized
0.010 GeneticVariation BEFREE SCN2A rs2304016 (<i>P</i> = 0.04) and GRM4 rs2499697 (<i>P</i> = 0.031) were statistically significant with generalized epilepsy. 31297029 2019
dbSNP: rs2499697
rs2499697
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0014544
Disease:
Epilepsy
0.010 GeneticVariation BEFREE This study identified no significant associations of allelic or genotypic SNPs with the susceptibility of epilepsy and medication response with an exception of rs2304016 and rs2499697 SNPs that were associated with the generalized type of epilepsy among Jordanian population. 31297029 2019
dbSNP: rs2499707
rs2499707
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0279702
Disease:
Conventional (Clear Cell) Renal Cell Carcinoma
0.010 GeneticVariation BEFREE Additional analysis has revealed a significant genotype-expression correlation of rs2499707 T with increased GRM4 expression, which in turn leads to poorer OS in patients with RCC. 30488581 2018
dbSNP: rs2499707
rs2499707
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0007134
Disease:
Renal Cell Carcinoma
0.010 GeneticVariation BEFREE Additional analysis has revealed a significant genotype-expression correlation of rs2499707 T with increased GRM4 expression, which in turn leads to poorer OS in patients with RCC. 30488581 2018
dbSNP: rs2029461
rs2029461
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0270853
Disease:
Juvenile Myoclonic Epilepsy
0.010 GeneticVariation BEFREE Of variants investigating in independent data sets, only rs2029461 SNP in GRM4, rs3743123 in CX36 and rs3918149 in BRD2 showed a significant association with JME in at least two different background populations. 28636645 2017
dbSNP: rs2229901
rs2229901
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE Functional studies are needed to clarify the possible mechanisms by which rs2229901 influences MDD risk. 27792966 2017
dbSNP: rs1906953
rs1906953
Entrez Id: 2914
Gene Symbol: GRM4
GRM4
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE The rs1906953 locus was not associated with Enneking stages or tumor location; however, it was associated significantly with OS metastasis and prognosis. 24984297 2014