|
rs11549465
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility.
|
31762805 |
2019 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
Subgroup analysis by ethnicity suggested that HIF1A Pro582Ser polymorphism might increase an individual's susceptibility to digestive tract cancer in Asian populations.
|
25117331 |
2014 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.
|
24063654 |
2013 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer.
|
15538748 |
2005 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation |
BEFREE |
When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC).
|
24824937 |
2014 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation |
BEFREE |
Compared with rs11549467 GG genotype, the variant genotypes GA+AA had a significantly increased PCa risk (adjusted odds ratio (OR)=1.70; 95% confidence interval (CI)=1.06-2.72), particularly among older patients (OR=2.01; 95%CI=1.05-3.86), smokers (OR=2.06; 95%CI=1.07-3.99), never drinkers (OR=2.16; 95%CI=1.20-3.86) and patients without a family history of cancer (OR=1.71; 95%CI=1.02-2.89).
|
23042446 |
2012 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs2057482 polymorphism was associated with decreased overall cancer risk, based on the currently available studies.
|
31744467 |
2019 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
Overall, C1772T and G1790A but not rs2057482 were associated with increased risk for cancer.
|
24046090 |
2014 |