DisGeNET - a database of gene-disease associations

HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1, 3117

N. diseases: 427; N. variants: 101

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs12722039

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0007570
Disease:

Celiac Disease

0.010

GeneticVariation

BEFREE

To investigate CTLA-4 exon 1 polymorphism (position 49 A/G) in patients with coeliac disease.

10189842

1998

dbSNP:

rs9272346

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0011854
Disease:

Diabetes Mellitus, Insulin-Dependent

0.810

GeneticVariation

GWASCAT

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

17554300

2007

dbSNP:

rs9272346

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0011854
Disease:

Diabetes Mellitus, Insulin-Dependent

0.810

GeneticVariation

GWASDB

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

17554300

2007

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0007570
Disease:

Celiac Disease

0.800

GeneticVariation

GWASDB

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

17558408

2007

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0007570
Disease:

Celiac Disease

0.800

GeneticVariation

GWASCAT

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

17558408

2007

dbSNP:

rs17211510

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0011854
Disease:

Diabetes Mellitus, Insulin-Dependent

0.700

GeneticVariation

GWASDB

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

17632545

2007

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0003873
Disease:

Rheumatoid Arthritis

0.700

GeneticVariation

GWASDB

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

17804836

2007

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0011854
Disease:

Diabetes Mellitus, Insulin-Dependent

0.700

GeneticVariation

GWASDB

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

17632545

2007

dbSNP:

rs9272346

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0026769
Disease:

Multiple Sclerosis

0.700

GeneticVariation

GWASDB

Risk alleles for multiple sclerosis identified by a genomewide study.

17660530

2007

dbSNP:

rs9272346

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0011854
Disease:

Diabetes Mellitus, Insulin-Dependent

0.810

GeneticVariation

GWASCAT

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

18978792

2008

dbSNP:

rs9272346

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0011854
Disease:

Diabetes Mellitus, Insulin-Dependent

0.810

GeneticVariation

GWASDB

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

18978792

2008

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0024141
Disease:

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASCAT

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

18204098

2008

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0024141
Disease:

Lupus Erythematosus, Systemic

0.800

GeneticVariation

GWASDB

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

18204098

2008

dbSNP:

rs9272219

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0036341
Disease:

Schizophrenia

0.800

GeneticVariation

GWASDB

Common variants on chromosome 6p22.1 are associated with schizophrenia.

19571809

2009

dbSNP:

rs9272219

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0036341
Disease:

Schizophrenia

0.800

GeneticVariation

GWASCAT

Common variants on chromosome 6p22.1 are associated with schizophrenia.

19571809

2009

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0242379
Disease:

Malignant neoplasm of lung

0.700

GeneticVariation

GWASDB

Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.

19654303

2009

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0152013
Disease:

Adenocarcinoma of lung (disorder)

0.700

GeneticVariation

GWASDB

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.

19836008

2009

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0003873
Disease:

Rheumatoid Arthritis

0.700

GeneticVariation

GWASDB

REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

19503088

2009

dbSNP:

rs9272346

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0027404
Disease:

Narcolepsy

0.700

GeneticVariation

GWASDB

Genome-wide association database developed in the Japanese Integrated Database Project.

19629137

2009

dbSNP:

rs9272535

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0036341
Disease:

Schizophrenia

0.700

GeneticVariation

GWASDB

Common variants on chromosome 6p22.1 are associated with schizophrenia.

19571809

2009

dbSNP:

rs9272723

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0027404
Disease:

Narcolepsy

0.700

GeneticVariation

GWASDB

Genome-wide association database developed in the Japanese Integrated Database Project.

19629137

2009

dbSNP:

rs17843604

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0004096
Disease:

Asthma

0.800

GeneticVariation

GWASDB

A large-scale, consortium-based genomewide association study of asthma.

20860503

2010

dbSNP:

rs2040406

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0026769
Disease:

Multiple Sclerosis

0.800

GeneticVariation

GWASCAT

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.

20453840

2010

dbSNP:

rs2040406

Entrez Id:	3117
Gene Symbol:	HLA-DQA1

HLA-DQA1

CUI:	C0026769
Disease:

Multiple Sclerosis

0.800

GeneticVariation

GWASDB

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.

20453840

2010

dbSNP:

rs2187668

Entrez Id:	3117;3118;107986589
Gene Symbol:	HLA-DQA1;HLA-DQA2;LOC107986589

HLA-DQA1;HLA-DQA2;LOC107986589

CUI:	C0007570
Disease:

Celiac Disease

0.800

GeneticVariation

GWASDB

Multiple common variants for celiac disease influencing immune gene expression.

20190752

2010