HTR1B, 5-hydroxytryptamine receptor 1B, 3351

N. diseases: 140; N. variants: 9
Disease: Major depression, single episode ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6296
rs6296
Entrez Id: 3351;105377864
Gene Symbol: HTR1B;LOC105377864
HTR1B;LOC105377864
CUI: C0024517
Disease:
Major depression, single episode 		0.010 GeneticVariation BEFREE Exploratory analyses indicated an association of the genotype and allele frequencies of the h5-HTR(1B) G861C locus with a history of substance abuse disorder (chi(2) = 9.51, df = 2, p = 0.009; chi(2) = 7.31, df = 1, p = 0.007, respectively) and with a diagnosis of a major depressive episode (chi(2) = 6.83, df = 2, p = 0.033; chi(2) = 5.81, df = 1, p = 0.016, respectively). 12496953 2003