|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Autoimmune Diseases
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Ulcerative Colitis
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Autoantibody measurement
|
G |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Multiple Sclerosis
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs1064794050
|
IGF2;MIR483;INS-IGF2
|
Russell-Silver syndrome
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1114167321
|
IGF2;MIR483;INS-IGF2
|
Russell-Silver syndrome
|
ACG |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs869320620
|
IGF2;MIR483;INS-IGF2
|
GROWTH RESTRICTION, SEVERE, WITH DISTINCTIVE FACIES
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs4320932
|
IGF2;INS-IGF2
|
Malignant neoplasm of ovary
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele of rs4320932, previously associated with decreased risk of ovarian cancer development, was here associated with significantly elevated risks of relapse (Ptrend = 0.0002) and death (Ptrend = 0.0006), remaining significant in multivariate analyses.
|
23677070 |
2013 |
|
rs4320932
|
IGF2;INS-IGF2
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele of rs4320932, previously associated with decreased risk of ovarian cancer development, was here associated with significantly elevated risks of relapse (Ptrend = 0.0002) and death (Ptrend = 0.0006), remaining significant in multivariate analyses.
|
23677070 |
2013 |
|
rs4320932
|
IGF2;INS-IGF2
|
ovarian neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele of rs4320932, previously associated with decreased risk of ovarian cancer development, was here associated with significantly elevated risks of relapse (Ptrend = 0.0002) and death (Ptrend = 0.0006), remaining significant in multivariate analyses.
|
23677070 |
2013 |
|
rs4320932
|
IGF2;INS-IGF2
|
Malignant neoplasm of ovary
|
|
0.020 |
GeneticVariation |
BEFREE |
In the combined set of studies, rs4320932 was associated with a 13% decreased risk of ovarian cancer per copy of the minor allele carried (95% confidence interval 0.81-0.93, P-trend=7.4 × 10(-5)).
|
21422097 |
2011 |
|
rs4320932
|
IGF2;INS-IGF2
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation |
BEFREE |
In the combined set of studies, rs4320932 was associated with a 13% decreased risk of ovarian cancer per copy of the minor allele carried (95% confidence interval 0.81-0.93, P-trend=7.4 × 10(-5)).
|
21422097 |
2011 |
|
rs4320932
|
IGF2;INS-IGF2
|
ovarian neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
In the combined set of studies, rs4320932 was associated with a 13% decreased risk of ovarian cancer per copy of the minor allele carried (95% confidence interval 0.81-0.93, P-trend=7.4 × 10(-5)).
|
21422097 |
2011 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms were associated with increased diabetes risk (rs10517086_A [<i>P</i> = 0.03], rs1534422_G [<i>P</i> = 0.006], and rs2327832_G [<i>P</i> = 0.03] in <i>TNFAIP3</i>) and one with decreased risk (rs1004446_A in <i>INS</i> [<i>P</i> = 0.006]).
|
28903990 |
2017 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms were associated with increased diabetes risk (rs10517086_A [<i>P</i> = 0.03], rs1534422_G [<i>P</i> = 0.006], and rs2327832_G [<i>P</i> = 0.03] in <i>TNFAIP3</i>) and one with decreased risk (rs1004446_A in <i>INS</i> [<i>P</i> = 0.006]).
|
28903990 |
2017 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Hyperglycemia
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis of the associations including data from 1367 Hyperglycaemia and Adverse Pregnancy Outcome Study participants confirmed the paternally-transmitted fetal IGF2/INS SNP associations (rs10770125, P-value=3.2×10<sup>-8</sup>, rs2585, P-value=3.6×10<sup>-5</sup>) and the composite fetal imprinted gene allele score association (P-value=1.3×10<sup>-8</sup>), but not the maternally-transmitted fetal KCNQ1(OT1) associations (rs231841, P-value=0.4; rs7929804, P-value=0.2).
|
28392167 |
2017 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Four fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value=2×10<sup>-4</sup>) and INS rs2585 (P-value=7×10<sup>-4</sup>), and maternally-transmitted KCNQ1(OT1) rs231841 (P-value=1×10<sup>-3</sup>) and KCNQ1(OT1) rs7929804 (P-value=4×10<sup>-3</sup>), were used to construct a composite fetal imprinted gene allele score which was associated with maternal glucose concentrations (P-value=4.3×10<sup>-6</sup>, n=981, r<sup>2</sup>=2.0%) and GDM prevalence (odds ratio per allele 1.44 (1.15, 1.80), P-value=1×10<sup>-3</sup>, n=89 cases and 899 controls).
|
28392167 |
2017 |
|
rs2585
|
IGF2;INS-IGF2
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Four fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value=2×10<sup>-4</sup>) and INS rs2585 (P-value=7×10<sup>-4</sup>), and maternally-transmitted KCNQ1(OT1) rs231841 (P-value=1×10<sup>-3</sup>) and KCNQ1(OT1) rs7929804 (P-value=4×10<sup>-3</sup>), were used to construct a composite fetal imprinted gene allele score which was associated with maternal glucose concentrations (P-value=4.3×10<sup>-6</sup>, n=981, r<sup>2</sup>=2.0%) and GDM prevalence (odds ratio per allele 1.44 (1.15, 1.80), P-value=1×10<sup>-3</sup>, n=89 cases and 899 controls).
|
28392167 |
2017 |
|
rs975030738
|
IGF2;MIR483;INS-IGF2
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
The tumor carried a heterozygous p.T41A mutation in CTNNB1.
|
27213811 |
2016 |
|
rs1003483
|
IGF2;IGF2-AS;INS-IGF2
|
Severe myopia
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in the INS-IGF2 region (rs2070762 and rs1003483), and the INSR gene (rs3745551 and rs2229429) showed significant association with HM (allelic P = 0.0085, 0.0494, 0.0171 and 0.0238, respectively).
|
25266237 |
2015 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation |
BEFREE |
IGF2 rs10770125 was also associated with DN in male T1D patients of the GoKinD population (P=0.038, OR=0.67 95% CI 0.46-0.98).
|
22770937 |
2013 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
IGF2 rs10770125 was also associated with DN in male T1D patients of the GoKinD population (P=0.038, OR=0.67 95% CI 0.46-0.98).
|
22770937 |
2013 |
|
rs680
|
IGF2;INS-IGF2
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association of four insulin-related pathway gene polymorphisms in insulin-like growth factor-1 (IGF-I) (CA)( n ) repeat, insulin-like growth factor-2 (IGF-II) (rs680), insulin-like growth factor-binding protein-3 (IGFBP-3) (rs2854744), and adiponectin (APM1 rs1501299) with colon cancer risk, as well as relationships with circulating IGF-I, IGF-II, IGFBP-3, and C-peptide in a population-based study.
|
22565227 |
2012 |
|
rs680
|
IGF2;INS-IGF2
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association of four insulin-related pathway gene polymorphisms in insulin-like growth factor-1 (IGF-I) (CA)( n ) repeat, insulin-like growth factor-2 (IGF-II) (rs680), insulin-like growth factor-binding protein-3 (IGFBP-3) (rs2854744), and adiponectin (APM1 rs1501299) with colon cancer risk, as well as relationships with circulating IGF-I, IGF-II, IGFBP-3, and C-peptide in a population-based study.
|
22565227 |
2012 |