|
rs20541
|
IL13;TH2LCRR
|
ALLERGIC RHINITIS, SUSCEPTIBILITY TO
|
G |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs20541
|
IL13;TH2LCRR
|
ASTHMA, SUSCEPTIBILITY TO (finding)
|
G |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs20541
|
IL13;TH2LCRR
|
Kaposi's sarcoma classical type
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared with controls, CKS risk was decreased with 1235T/-1010G-containing diplotypes of IL8RB (odds ratio, 0.49; 95% confidence interval, 0.30-0.78; P = 0.003), whereas risk was increased with diplotypes of IL13 containing the promoter region variant 98A (rs20541, alias +130; odds ratio, 1.88; 95% confidence interval, 1.15-3.08; P = 0.01) when considered in multivariate analysis.
|
16702372 |
2006 |
|
rs1800925
|
IL13;TH2LCRR
|
Asthma
|
|
0.090 |
GeneticVariation |
BEFREE |
Although this SNP (rs1800925) was not associated with asthma exacerbations among all white children in CAMP, it was associated with increased risk of asthma exacerbations among children on inhaled corticosteroids (P = .02).
|
17561245 |
2007 |
|
rs1800925
|
IL13;TH2LCRR
|
Childhood Glioblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
To see whether previous Swedish results (110 cases, 430 controls) would be replicated, we estimated the association between glioblastoma and two IL-4Ralpha (rs1805015, rs1801275) and two IL-13 (rs20541, rs1800925) SNPs and their haplotypes and one COX-2 SNP (-765GC) using additional English, Danish, and Finnish data (217 cases, 1,171 controls).
|
18006935 |
2007 |
|
rs1800925
|
IL13;TH2LCRR
|
Glioblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
To see whether previous Swedish results (110 cases, 430 controls) would be replicated, we estimated the association between glioblastoma and two IL-4Ralpha (rs1805015, rs1801275) and two IL-13 (rs20541, rs1800925) SNPs and their haplotypes and one COX-2 SNP (-765GC) using additional English, Danish, and Finnish data (217 cases, 1,171 controls).
|
18006935 |
2007 |
|
rs1800925
|
IL13;TH2LCRR
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation |
BEFREE |
To see whether previous Swedish results (110 cases, 430 controls) would be replicated, we estimated the association between glioblastoma and two IL-4Ralpha (rs1805015, rs1801275) and two IL-13 (rs20541, rs1800925) SNPs and their haplotypes and one COX-2 SNP (-765GC) using additional English, Danish, and Finnish data (217 cases, 1,171 controls).
|
18006935 |
2007 |
|
rs1800925
|
IL13;TH2LCRR
|
Adult Glioblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
To see whether previous Swedish results (110 cases, 430 controls) would be replicated, we estimated the association between glioblastoma and two IL-4Ralpha (rs1805015, rs1801275) and two IL-13 (rs20541, rs1800925) SNPs and their haplotypes and one COX-2 SNP (-765GC) using additional English, Danish, and Finnish data (217 cases, 1,171 controls).
|
18006935 |
2007 |
|
rs1800925
|
IL13;TH2LCRR
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation |
BEFREE |
A model with rs1058240, rs379568, and rs4143094 (GATA3) and rs1800925 (IL13) and their interactions was selected to predict rhinitis and positive SPT responses. rs1058240 was associated with rhinitis and allergic rhinitis (P < .05), and the gene-gene interaction rs1058240:rs1800925 was associated with rhinitis (P = .043).
|
18037162 |
2008 |
|
rs1800925
|
IL13;TH2LCRR
|
Rhinitis
|
|
0.020 |
GeneticVariation |
BEFREE |
A model with rs1058240, rs379568, and rs4143094 (GATA3) and rs1800925 (IL13) and their interactions was selected to predict rhinitis and positive SPT responses. rs1058240 was associated with rhinitis and allergic rhinitis (P < .05), and the gene-gene interaction rs1058240:rs1800925 was associated with rhinitis (P = .043).
|
18037162 |
2008 |
|
rs20541
|
IL13;TH2LCRR
|
Psoriasis
|
|
0.860 |
GeneticVariation |
BEFREE |
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis.
|
18075513 |
2008 |
|
rs848
|
IL13;TH2LCRR
|
Psoriasis
|
|
0.020 |
GeneticVariation |
BEFREE |
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis.
|
18075513 |
2008 |
|
rs1800925
|
IL13;TH2LCRR
|
Psoriasis
|
|
0.010 |
GeneticVariation |
BEFREE |
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis.
|
18075513 |
2008 |
|
rs20541
|
IL13;TH2LCRR
|
Psoriasis
|
G |
0.860 |
GeneticVariation |
GWASDB |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
rs20541
|
IL13;TH2LCRR
|
Psoriasis
|
G |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
rs20541
|
IL13;TH2LCRR
|
Asthma
|
|
0.800 |
GeneticVariation |
BEFREE |
We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth.
|
19254294 |
2009 |
|
rs1800925
|
IL13;TH2LCRR
|
Asthma
|
|
0.090 |
GeneticVariation |
BEFREE |
We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth.
|
19254294 |
2009 |
|
rs20541
|
IL13;TH2LCRR
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin 13 (IL13) Ex4+98A>G SNP (rs20541) was associated with decreased NHL risk (OR(AG/AA) = 0.62,95% CI = 0.44-0.87, p = 0.006), as was vascular cell adhesion molecule-1, VCAM1 Ex9+149G>A SNP (rs1041163) (OR(CT) = 0.77, 95% CI = 0.54-1.10, OR(CC) = 0.35, 95% CI = 0.16-0.76, p-trend = 0.007).
|
19533685 |
2009 |
|
rs20541
|
IL13;TH2LCRR
|
Asthma
|
|
0.800 |
GeneticVariation |
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
rs1800925
|
IL13;TH2LCRR
|
Asthma
|
|
0.090 |
GeneticVariation |
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
rs1800925
|
IL13;TH2LCRR
|
Arthritis, Psoriatic
|
|
0.030 |
GeneticVariation |
BEFREE |
We examined the association between IL13 polymorphisms, smoking, and PsA in two Ps sample sets genotyped for rs1800925, rs20541, and rs848.
|
19554022 |
2009 |
|
rs848
|
IL13;TH2LCRR
|
Arthritis, Psoriatic
|
|
0.020 |
GeneticVariation |
BEFREE |
We examined the association between IL13 polymorphisms, smoking, and PsA in two Ps sample sets genotyped for rs1800925, rs20541, and rs848.
|
19554022 |
2009 |
|
rs20541
|
IL13;TH2LCRR
|
Wheezing
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a statistically significant association between the IL-13 Arg144Gln polymorphism and risk of recurrent wheeze (p = 0.01).
|
19674346 |
2009 |
|
rs1800925
|
IL13;TH2LCRR
|
Asthma
|
|
0.090 |
GeneticVariation |
BEFREE |
IL13 SNPs rs1881457(-1512) and rs1800925(-1111) were associated with better FEV(1) and FEV(1)/FVC in asthmatics.
|
19796199 |
2010 |
|
rs20541
|
IL13;TH2LCRR
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
IL13 SNPs rs2066960(intron 1), rs20541(R130Q) and rs1295685(exon 4) were associated with COPD risk and lower baseline lung function in the recessive model.
|
19796199 |
2010 |