|
rs1800925
|
IL13;TH2LCRR
|
Appendicitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations with appendicitis were found for SNPs IL-13 rs1800925 with odds ratio (OR) 6.02 (95% CI 1.52-23.78) for T/T versus C/C + T/T, for IL-17 rs2275913 with OR 2.38 (CI 1.24-4.57) for A/A vs G/G + GA, for CCL22 rs223888 with OR 0.12 (0.02-0.90), and for A/A vs G/G + GA. Signs of effect modification of age for the association with appendicitis were found for IL-13 rs1800925 and CTLA4 rs3087243.
|
31845023 |
2020 |
|
rs1800925
|
IL13;TH2LCRR
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no SNP was associated with breast cancer risk among women of European descent, we found evidence for an association among East Asians for rs1800925 (IL-13) and breast cancer risk (OR = 2.08; 95% CI: 1.32-3.28; p = 0.000779), which remained statistically significant after multiple testing correction (padj = 0.0350).
|
30601841 |
2019 |
|
rs1800925
|
IL13;TH2LCRR
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no SNP was associated with breast cancer risk among women of European descent, we found evidence for an association among East Asians for rs1800925 (IL-13) and breast cancer risk (OR = 2.08; 95% CI: 1.32-3.28; p = 0.000779), which remained statistically significant after multiple testing correction (padj = 0.0350).
|
30601841 |
2019 |
|
rs20541
|
IL13;TH2LCRR
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results, the first report, provide evidence that rs20541 polymorphisms may affect the lymph node metastasis of NPC patients in Chinese population.
|
30472105 |
2019 |
|
rs20541
|
IL13;TH2LCRR
|
Hand, Foot and Mouth Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele at the rs20541 locus of IL-13 gene and the A allele at the rs179019 locus of the TLR-7 gene were not risk factors for severe HFMD in either male or female patients.
|
30807256 |
2019 |
|
rs1800925
|
IL13;TH2LCRR
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate IL-13 SNP rs1800925 as a risk factor for CRC and that IL-4 SNP rs2243250 could be a useful prognostic marker in the follow-up and clinical management of patients with CRC especially in stage III disease.
|
30227113 |
2018 |
|
rs20541
|
IL13;TH2LCRR
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls.
|
29670225 |
2018 |
|
rs20541
|
IL13;TH2LCRR
|
Rhinitis
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) and GSTP1 (rs1695) genes are associated with rhinitis and/or asthma in adults of Portuguese ancestry.
|
27561723 |
2018 |
|
rs20541
|
IL13;TH2LCRR
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs2</span>0541 CT/TT genotypes may be a risk factor for SLE, probably by increasing the level of IL-13.
|
29017771 |
2018 |
|
rs1295686
|
IL13;TH2LCRR
|
IgE-mediated food allergy
|
|
0.010 |
GeneticVariation |
BEFREE |
We show for the first time, in two independent cohorts, that IL13 polymorphism rs1295686 (in complete linkage disequilibrium with functional variant rs20541) is associated with challenge-proven food allergy.
|
28544327 |
2017 |
|
rs20541
|
IL13;TH2LCRR
|
IgE-mediated food allergy
|
|
0.010 |
GeneticVariation |
BEFREE |
We show for the first time, in two independent cohorts, that IL13 polymorphism rs1295686 (in complete linkage disequilibrium with functional variant rs20541) is associated with challenge-proven food allergy.
|
28544327 |
2017 |
|
rs20541
|
IL13;TH2LCRR
|
Allergic Conjunctivitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Our aim was to observe factors associated with IL13 rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and/or allergic conjunctivitis (AC) symptoms in adult asthmatics.
|
28273659 |
2017 |
|
rs20541
|
IL13;TH2LCRR
|
Actinic cheilitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Our aim was to observe factors associated with IL13 rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and/or allergic conjunctivitis (AC) symptoms in adult asthmatics.
|
28273659 |
2017 |
|
rs848
|
IL13;TH2LCRR
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the three SNPs showed no statistically significant associations with the risk and prognosis of CRC, a significant antagonistic interaction was found between rs848 (G-T) and allium vegetable intake (ORi (odds ratio of interaction), 0.92; 95% CI (confidence interval): 0.86, 0.99; P = 0.03); moreover, significant combined and synergistic interactions were observed for all three SNPs and overnight meal intake.
|
28537887 |
2017 |
|
rs1800925
|
IL13;TH2LCRR
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation |
BEFREE |
However, stratification analyses suggested that the IL-13 rs1800925 CT and CT/CC genotypes increased the risk of RA in patients with erythrocyte sedimentation rate (ESR) <25.00.
|
27323078 |
2016 |
|
rs1800925
|
IL13;TH2LCRR
|
Rectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Can an IL13 -1112 C/T (rs1800925) polymorphism predict responsiveness to neoadjuvant chemoradiotherapy and survival of Chinese Han patients with locally advanced rectal cancer?
|
27167201 |
2016 |
|
rs1800925
|
IL13;TH2LCRR
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association between rs2070874 or rs1800925 and CP was found, while the frequencies of rs2243248 and two haplotypes C-G-T and C-T-T showed significant differences between the two groups.
|
27195298 |
2016 |
|
rs20541
|
IL13;TH2LCRR
|
Community acquired pneumonia
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied common polymorphisms in the genes of proinflammatory cytokines (IL6 rs1800795, IL8 rs4073, IL1B rs16944), anti-inflammatory cytokines (IL10 rs1800896, IL4 rs2243250, IL13 rs20541) and toll-like receptors (TLR2 rs5743708 and rs4696480, TLR4 rs4986791, TLR9 rs352139, rs5743836 and rs187084) in patients with community-acquired pneumonia (CAP) (390 cases, 203 controls) and nosocomial pneumonia (355 cases, 216 controls).
|
27725770 |
2016 |
|
rs20541
|
IL13;TH2LCRR
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Each of the four SNPs was identified to have an independent association with childhood asthma (G allele of rs20541, odds ratio (OR) = 1.24, P = 1.23E-03; T allele of rs2243250, OR = 1.25, P = 3.81E-03; A allele of rs1042713, OR = 1.29, P = 6.75E-05; G allele of rs569108, OR = 1.27, P = 3.86E-03).
|
26613553 |
2016 |
|
rs20541
|
IL13;TH2LCRR
|
CATARACT, ANTERIOR POLAR
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied common polymorphisms in the genes of proinflammatory cytokines (IL6 rs1800795, IL8 rs4073, IL1B rs16944), anti-inflammatory cytokines (IL10 rs1800896, IL4 rs2243250, IL13 rs20541) and toll-like receptors (TLR2 rs5743708 and rs4696480, TLR4 rs4986791, TLR9 rs352139, rs5743836 and rs187084) in patients with community-acquired pneumonia (CAP) (390 cases, 203 controls) and nosocomial pneumonia (355 cases, 216 controls).
|
27725770 |
2016 |
|
rs848
|
IL13;TH2LCRR
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for multiple testing and potential confounders, SNP rs848 in the IL13 gene region is significantly associated with a continuous measure of symptom severity in adult subjects with ever asthma.
|
26986948 |
2016 |
|
rs1295686
|
IL13;TH2LCRR
|
Sleep onset Insomnia
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for genomic estimates of ancestry, self-reported race/ethnicity and viral load, SOI was associated with higher IL-13 plasma levels and with six single nucleotide polymorphisms (SNPs): IL1B rs1143642 and rs1143623, IL6 rs4719714, IL13 rs1295686, NFKB1 rs4648110, and TNFA rs2857602.
|
25535857 |
2015 |
|
rs1800925
|
IL13;TH2LCRR
|
Leukopenia
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele in IL13 rs1800925 was associated with an increase in the risk of leukopenia (OR = 6.76, 95 % CI = 1.35-33.9, P = 0.020) and increased prevalence of any toxicity > grade 2 (OR = 1.75, 95 % CI = 1.06-2.88, P = 0.028).
|
26387812 |
2015 |
|
rs1800925
|
IL13;TH2LCRR
|
Hepatitis B
|
|
0.010 |
GeneticVariation |
BEFREE |
This study was undertaken to determine the relationship between two IL-13 gene single nucleotide polymorphisms (SNP rs1800925 and SNP rs20541) and the incidence of hepatitis B virus-related (HBV) hepatocellular carcinoma (HCC).
|
25658755 |
2015 |
|
rs1800925
|
IL13;TH2LCRR
|
Liver carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
This study was undertaken to determine the relationship between two IL-13 gene single nucleotide polymorphisms (SNP rs1800925 and SNP rs20541) and the incidence of hepatitis B virus-related (HBV) hepatocellular carcinoma (HCC).
|
25658755 |
2015 |