GSTK1, glutathione S-transferase kappa 1, 373156

N. diseases: 445; N. variants: 10
Disease: Breast Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1242405057
rs1242405057
Entrez Id: 373156;105375545
Gene Symbol: GSTK1;LOC105375545
GSTK1;LOC105375545
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity. 20670164 2010
dbSNP: rs200469041
rs200469041
Entrez Id: 373156;105375545
Gene Symbol: GSTK1;LOC105375545
GSTK1;LOC105375545
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity. 20670164 2010
dbSNP: rs1242405057
rs1242405057
Entrez Id: 373156;105375545
Gene Symbol: GSTK1;LOC105375545
GSTK1;LOC105375545
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing. 17180579 2007
dbSNP: rs200469041
rs200469041
Entrez Id: 373156;105375545
Gene Symbol: GSTK1;LOC105375545
GSTK1;LOC105375545
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing. 17180579 2007
dbSNP: rs866838052
rs866838052
Entrez Id: 373156;105375545
Gene Symbol: GSTK1;LOC105375545
GSTK1;LOC105375545
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Association of GSTO1 A140D and GSTO2 N142D Gene Variations with Breast Cancer Risk 28670895 2017
dbSNP: rs764342874
rs764342874
Entrez Id: 373156;105375545;105375546
Gene Symbol: GSTK1;LOC105375545;LOC105375546
GSTK1;LOC105375545;LOC105375546
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy. 18058229 2008