KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Disease: ovarian neoplasm ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		G 0.710 CausalMutation CLINVAR Epidermal growth factor receptor blockers for the treatment of ovarian cancer. 21975775 2011
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR Epidermal growth factor receptor blockers for the treatment of ovarian cancer. 21975775 2011
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		0.710 GeneticVariation BEFREE In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer. 21632463 2011
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		A 0.710 CausalMutation CLINVAR Epidermal growth factor receptor blockers for the treatment of ovarian cancer. 21975775 2011
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. 19358724 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		G 0.710 CausalMutation CLINVAR KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. 19018267 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. 19018267 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. 17910045 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		A 0.710 CausalMutation CLINVAR KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. 19018267 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205 2005
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.710 CausalMutation CLINVAR Somatic PTPN11 mutations in childhood acute myeloid leukaemia. 15842656 2005
dbSNP: rs112445441
rs112445441
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.700 CausalMutation CLINVAR Epidermal growth factor receptor blockers for the treatment of ovarian cancer. 21975775 2011
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		G 0.700 CausalMutation CLINVAR Epidermal growth factor receptor blockers for the treatment of ovarian cancer. 21975775 2011
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		A 0.700 CausalMutation CLINVAR Epidermal growth factor receptor blockers for the treatment of ovarian cancer. 21975775 2011
dbSNP: rs112445441
rs112445441
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		T 0.700 CausalMutation CLINVAR KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. 19018267 2008
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		G 0.700 CausalMutation CLINVAR KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. 19018267 2008
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		A 0.700 CausalMutation CLINVAR KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. 19018267 2008
dbSNP: rs61764370
rs61764370
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		0.030 GeneticVariation BEFREE Recently, a variant allele in the 3'UTR of the KRAS gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families. 20676756 2011
dbSNP: rs61764370
rs61764370
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		0.030 GeneticVariation BEFREE These data exclude the possibility of an association between rs61764370 and a clinically significant risk of ovarian cancer or of familial ovarian cancer. 21385923 2011
dbSNP: rs61764370
rs61764370
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		0.030 GeneticVariation BEFREE In this study, we investigated a hypothesized association between an increased risk of OC and a variant allele of KRAS at rs61764370, referred to as the KRAS-variant, which disrupts a let-7 miRNA binding site in this oncogene. 20647319 2010