|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
GWASDB |
HTRA1 promoter polymorphism in wet age-related macular degeneration.
|
17053108 |
2006 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
Two SNPs generated highly significant allelic associations with PCV (rs10490924, P = 5.7 x 10(-6); rs11200638, P = 5.2 x 10(-6)) and AMD (rs10490924, P = 1.4 x 10(-6); rs11200638, P = 3.4 x 10(-7)).
|
17692272 |
2007 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
We propose that rs10490924 represents a major susceptibility variant for AMD at 10q26.
|
17884985 |
2007 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
The AMD cases possessing the LOC387715 (rs10490924) variant may have a higher risk of neovascular AMD.
|
17210853 |
2007 |
|
rs10490924
|
ARMS2;LOC105378525
|
Glycogen storage disease type II
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SNPs generated highly significant allelic associations with PCV (rs10490924, P = 5.7 x 10(-6); rs11200638, P = 5.2 x 10(-6)) and AMD (rs10490924, P = 1.4 x 10(-6); rs11200638, P = 3.4 x 10(-7)).
|
17692272 |
2007 |
|
rs10490924
|
ARMS2;LOC105378525
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SNPs generated highly significant allelic associations with PCV (rs10490924, P = 5.7 x 10(-6); rs11200638, P = 5.2 x 10(-6)) and AMD (rs10490924, P = 1.4 x 10(-6); rs11200638, P = 3.4 x 10(-7)).
|
17692272 |
2007 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant associations were detected for exudative AMD with SNPs rs10490924:G>T in LOC387715 (A69S), and rs11200638:G>A in the promoter of HTRA1.
|
18682812 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10</span>490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
Using DNA extracted from venous blood of 876 white participants in AREDS categories 3 and 4, that is, those considered to be at high risk for progression to advanced AMD, the authors genotyped for the single nucleotide polymorphisms in the CFH (Y402H, rs1061170) and LOC387715/ARMS2 (A69S, rs10490924) genes.
|
18423869 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
Homozygotes for the T allele of rs10490924 had an odds ratio (OR) of 8.6, with a 95% confidence interval (CI) of 3.5-20.8, and homozygotes for the A allele of rs11200638 had an OR of 10.7, with a 95% CI of 3.2-35.7, for having AMD (p<0.00001).
|
19065273 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs10490924 polymorphism, the major determinant of the 10q26 association with ARMD, determines the A69S substitution in the LOC387715/ARMS2 gene.
|
18688167 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped three SNPs, rs1061170 (exon 9, CFH), rs11200638 (HTRA1 promoter, -512 bp), and rs10490924 (6.6 kb upstream of HTRA1 in LOC387715/ARMS2) in 333 cases with advanced AMD (choroidal neovascularization [CNV] and geographic atrophy) and 171 age-matched examined controls.
|
18682806 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine phenotypes of age-related macular degeneration (AMD) patients with the LOC387715 variant (T allele at rs10490924, A69S).
|
18061132 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the LOC387715 (rs10490924), HTRA1 (rs11200638), and CFH (rs1061170) genes have been implicated in age-related macular degeneration (AMD).
|
18436811 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Geographic Atrophy
|
|
0.800 |
GeneticVariation |
BEFREE |
We genotyped three SNPs, rs1061170 (exon 9, CFH), rs11200638 (HTRA1 promoter, -512 bp), and rs10490924 (6.6 kb upstream of HTRA1 in LOC387715/ARMS2) in 333 cases with advanced AMD (choroidal neovascularization [CNV] and geographic atrophy) and 171 age-matched examined controls.
|
18682806 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Glycogen storage disease type II
|
|
0.100 |
GeneticVariation |
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10</span>490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation |
BEFREE |
The AA genotype of rs11200638 and TT genotype of rs10490924 conferred a 4.9-fold (95% CI: 1.85-12.95) and 4.89-fold (95% CI: 1.85-12.90) increased risk of PCV, respectively, after adjustment for age and sex.
|
18515590 |
2008 |
|
rs2736911
|
ARMS2;LOC105378525
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of their distribution in 213 AD patients and 149 controls revealed a trend for a reduced frequency of the variant allele of rs2736911 in AD patients (p = 0.038), with an odds ratio of 0.631.
|
18688167 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed that homozygous risk genotypes (TT in rs10490924 and AA in rs11200638) were more strongly associated with AMD than the heterozygous genotypes (GT in rs10490924 and geographic atrophy in rs11200638) for both SNPs.
|
19491722 |
2009 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs10490924 on chromosome 10 in exon 1 of the ARMS2 gene showed a highly significant association with an odds ratio (OR) of 3.2 (95% CI 2.4-4.2) for the risk allele and rs11200638 located in the proximal promoter region of HTRA1 showed a higher significant association with an OR of 3.4 (95% CI 2.5-4.6) with our AMD cases.
|
19259132 |
2009 |
|
rs10490924
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation |
BEFREE |
One haplotype, which contained the T allele of the rs10490924 (A69S) and the variant of de1443ins54 polymorphism, had an odds ratio of 3.14 (P = 7.8 x 10(-6)) for AMD and 2.00 (P = .0058) for PCV.
|
19268887 |
2009 |
|
rs10490924
|
ARMS2;LOC105378525
|
Geographic Atrophy
|
|
0.800 |
GeneticVariation |
BEFREE |
We observed that homozygous risk genotypes (TT in rs10490924 and AA in rs11200638) were more strongly associated with AMD than the heterozygous genotypes (GT in rs10490924 and geographic atrophy in rs11200638) for both SNPs.
|
19491722 |
2009 |
|
rs10490924
|
ARMS2;LOC105378525
|
Geographic Atrophy
|
|
0.800 |
GeneticVariation |
BEFREE |
In a subset of 99 cases with pure bilateral GA, variants in CFH (Y402H), C3 (R102G), and ARMS2 (A69S) are associated with disease (P = 1.6x10(-9), 3.2x10(-3), and P = 2.6x10(-12), respectively) when compared to 612 unrelated healthy control individuals.
|
19823576 |
2009 |
|
rs10490924
|
ARMS2;LOC105378525
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation |
BEFREE |
One haplotype, which contained the T allele of the rs10490924 (A69S) and the variant of de1443ins54 polymorphism, had an odds ratio of 3.14 (P = 7.8 x 10(-6)) for AMD and 2.00 (P = .0058) for PCV.
|
19268887 |
2009 |
|
rs10490924
|
ARMS2;LOC105378525
|
Polypoidal choroidal vasculopathy
|
|
0.100 |
GeneticVariation |
BEFREE |
The LOC387715 A69S genotype is not associated with lesion composition or size on indocyanine green angiography but with lesion size on fluorescein angiography in patients with subfoveal polypoidal choroidal vasculopathy.
|
19898184 |
2009 |