|
rs3750847
|
ARMS2;LOC105378525
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Incident early AMD was associated with cardiovascular disease history (HR 1.59, 95% CI 1.04-2.45), underweight body mass index (BMI) (HR 3.12, 95% CI 1.37-7.14) (BMI of <18.5 vs 18.51-25 kg/m2), heavy alcohol drinking (HR 3.14 95% CI 1.25-7.89) and ARMS2 rs3750847 homozygous genetic loci carrier (HR 2.52, 95% CI 1.59-3.99).
|
29891972 |
2018 |
|
rs36212732
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the AMD-risk SNPs (rs36212732 and rs36212733) affect transcription factor binding sites in proximity to a DNase I hypersensitive region (i.e., a region of open chromatin) in RPE cells.
|
28659708 |
2017 |
|
rs36212733
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the AMD-risk SNPs (rs36212732 and rs36212733) affect transcription factor binding sites in proximity to a DNase I hypersensitive region (i.e., a region of open chromatin) in RPE cells.
|
28659708 |
2017 |
|
rs10490924
|
ARMS2;LOC105378525
|
Central Serous Chorioretinopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with CVH had a significantly higher frequency of the G allele of ARMS2 A69S (rs10490924) and the T allele of CFH (rs1329428), which are reported to be risk alleles for central serous chorioretinopathy (P = 0.006 and P = 0.032, respectively; multivariate regression analysis).
|
26745149 |
2016 |
|
rs3750847
|
ARMS2;LOC105378525
|
Exudative age-related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
After cross-validation consistency (CVC) and permutation tests, the two-locus model rs2274700_rs3750847 has a balanced accuracy of 64.37% in predicting nAMD disease risk.
|
25771815 |
2015 |
|
rs3750847
|
ARMS2;LOC105378525
|
Polypoidal choroidal vasculopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
The one-marker model, rs3750847, and two-locus model rs2274700_rs3750847 has a balanced accuracy of 66.07% and 65.89% in predicting PCV disease risk, respectively.
|
25771815 |
2015 |
|
rs10490923
|
ARMS2;LOC105378525
|
Glycogen storage disease type II
|
|
0.010 |
GeneticVariation |
BEFREE |
CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) gene polymorphisms are associated with AMD risk in Spanish patients.
|
23534868 |
2014 |
|
rs2736911
|
ARMS2;LOC105378525
|
Exudative age-related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
A69S and R38X ARMS2 and Y402H CFH gene polymorphisms as risk factors for neovascular age-related macular degeneration in Poland - a brief report.
|
22293892 |
2012 |
|
rs10490924
|
ARMS2;LOC105378525
|
Serous retinal detachment
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the at-risk allele of ARMS2 A69S was associated with a lower incidence of serous retinal detachment (P = 0.0092).
|
21397333 |
2011 |
|
rs10490924
|
ARMS2;LOC105378525
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
In HTRA1, rs11200638 (G>A), showed marginal significance with DR (P = 0.055) while rs10490924 in LOC387715 gave a P = 0.07.
|
21067572 |
2010 |
|
rs10664316
|
ARMS2;LOC105378525
|
Drusen
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphisms rs10664316 and rs1049331 were associated with a decreased risk of poor visual acuity during follow-up and at diagnosis; rs2672598 and rs2293870 were associated with a decreased risk of RPE hyperpigmentation; rs10664316 was associated with a decreased risk of RPE hyperpigmentation with large drusen in the study eye, but an increased risk of large drusen in the fellow eye; rs11200638 was associated with an increased risk of larger CNV; rs10490924 and rs11200638 were associated with younger age of diagnosis.
|
19796758 |
2009 |
|
rs2736911
|
ARMS2;LOC105378525
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of their distribution in 213 AD patients and 149 controls revealed a trend for a reduced frequency of the variant allele of rs2736911 in AD patients (p = 0.038), with an odds ratio of 0.631.
|
18688167 |
2008 |
|
rs10490924
|
ARMS2;LOC105378525
|
Blindness
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphism rs10490924 (A69S) in the age-related maculopathy susceptibility 2 (ARMS2) gene is highly associated with age-related macular degeneration, which is the leading cause of blindness among the elderly population.
|
29316486 |
2018 |
|
rs10490924
|
ARMS2;LOC105378525
|
Blindness
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphism rs10490924 (A69S) in the age-related maculopathy susceptibility 2 (ARMS2) gene is highly associated with age-related macular degeneration, which is the leading cause of blindness among the elderly population.
|
28915445 |
2017 |
|
rs10490924
|
ARMS2;LOC105378525
|
Retinal pigment epithelium atrophy
|
|
0.020 |
GeneticVariation |
BEFREE |
Baseline characteristics and gene polymorphisms of ARMS2 A69S, and CFH I62V were analyzed for association with development and progression of RPE atrophy.
|
28085772 |
2017 |
|
rs10490924
|
ARMS2;LOC105378525
|
Retinal Pigment Epithelial Detachment
|
|
0.020 |
GeneticVariation |
BEFREE |
In 81 patients who completed 12-month anti-VEGF monotherapy without photodynamic therapy, significant pharmacogenetic association was found between ARMS2 rs10490924 and PED regression on OCT. Proportions of PED regression were 26.4% for TT, 45.7% for TG, and 63.6% for GG genotype, showing additive effect of G allele for higher chance of PED regression (OR, 2.96; 95% CI, 1.38-6.36; corrected P = 0.043).
|
29212537 |
2017 |
|
rs10490924
|
ARMS2;LOC105378525
|
Retinal pigment epithelium atrophy
|
|
0.020 |
GeneticVariation |
BEFREE |
The ARMS2 A69S and CFH I62V polymorphisms were significantly associated with the baseline RPE atrophy (P = .014 and P = .009, respectively).
|
26432927 |
2016 |
|
rs10490924
|
ARMS2;LOC105378525
|
Choroidal vascular hyperpermeability
|
|
0.020 |
GeneticVariation |
BEFREE |
Subfoveal choroidal thickness and CVH in eyes with treatment-naive polypoidal choroidal vasculopathy were associated with ARMS2 A69S (rs10490924) and CFH (rs1329428).
|
26745149 |
2016 |
|
rs10490923
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show that genotypes of ARMS2 (rs10490923), HTRA1 (rs112000638) and CFH (rs1410996) polymorphisms are related to an increased risk of suffering AMD in Spanish patients.
|
23534868 |
2014 |
|
rs10490924
|
ARMS2;LOC105378525
|
Choroidal vascular hyperpermeability
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotype distributions of ARMS2 (A69S) and CFH (I62V) in patients with CVH and type 1 CNV significantly differed from those of AMD cases (P = 0.0014 and 0.0098, respectively), but not from general population controls (P = 0.33 and 0.82, statistical power of 88.5% and 72.9%, respectively).
|
24781946 |
2014 |
|
rs10490923
|
ARMS2;LOC105378525
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation |
BEFREE |
In the ARMS2 locus, RS10490924 was associated with both early (adjusted RR 1.22, 95% confidence interval [CI]: 1.13-1.33, P < 0.0001) and late AMD (adjusted RR 1.81, 95% CI: 1.15-2.86; P = 0.01); rs2672598 was associated only with early AMD (adjusted RR 1.12, 95% CI: 1.02-1.23; P = 0.02); rs10490923 was not associated with early or late AMD.
|
23060141 |
2012 |
|
rs10490924
|
ARMS2;LOC105378525
|
Retinal Pigment Epithelial Detachment
|
|
0.020 |
GeneticVariation |
BEFREE |
In particular, the at-risk allele homozygosity of ARMS2 A69S increased the likelihood for hemorrhagic PED by 12.4-fold compared with non-carriers of the allele (confidence interval, 1.60-95.1, P = 0.0001).
|
21397333 |
2011 |
|
rs10490924
|
ARMS2;LOC105378525
|
Reticular pseudodrusen
|
|
0.040 |
GeneticVariation |
BEFREE |
Six single nucleotide polymorphisms-rs10490924 (ARMS2), rs1061170 (CFH), rs2230199 (C3), rs116503776 and rs114254831 (C2/CFB), and rs943080 (VEGF-A)-and the genetic risk score (GRS) were assessed for association with RPD.
|
31558345 |
2019 |
|
rs10490924
|
ARMS2;LOC105378525
|
Reticular pseudodrusen
|
|
0.040 |
GeneticVariation |
BEFREE |
Comparison of above-mentioned ORs revealed statistically higher values for GT and TT genotypes of ARMS2 A69S compared with CFH Y402H genotypes (p = 0.011, p = 0.014, respectively).Our analysis showed stronger contribution of ARMS2 in AMD with RPD group versus AMD without RPD group, in comparison with CFH genotypes.
|
28593728 |
2018 |
|
rs10490924
|
ARMS2;LOC105378525
|
Reticular pseudodrusen
|
|
0.040 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that age (odds ratio [OR]:1.10; 95% confidence interval [CI]: 1.04-1.18; p = 0.002), female gender (OR:4.26; 95%CI: 1.72-10.4; p = 0.002), T-allele at ARMS2 A69S (OR: 3.23; 95%CI: 1.36-7.68; p = 0.008) and RAP (OR: 4.25; 95%CI:1.49-12.1; p = 0.007) were risk factors for RPD.
|
24595987 |
2014 |