ASIC2, acid sensing ion channel subunit 2, 40

N. diseases: 33; N. variants: 4
Source: BEFREE ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs378448
rs378448
Entrez Id: 40
Gene Symbol: ASIC2
ASIC2
CUI: C0005586
Disease:
Bipolar Disorder 		0.010 GeneticVariation BEFREE Our preliminary findings suggest that rs378448 could predispose BD subjects to a detrimental effect of chronic Li treatment on kidney functioning. 27923663 2017
dbSNP: rs17836917
rs17836917
Entrez Id: 40
Gene Symbol: ASIC2
ASIC2
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE In the combined analyses, we discovered two novel loci associated with CRC: rs12522693 at 5q23.3 (CDC42SE2-CHSY3, OR = 1.31, P = 2.08 × 10-8) and rs17836917 at 17q12 (ASIC2-CCL2, OR = 0.75, P = 4.55 × 10-8). 26515597 2015
dbSNP: rs1194556417
rs1194556417
Entrez Id: 40
Gene Symbol: ASIC2
ASIC2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.010 GeneticVariation BEFREE Cross-breeding of SOD1(G93A) ALS mice with asic1a-deficient mice delayed the onset and progression of motor dysfunction in SOD1 mice. 23306556 2013
dbSNP: rs28936
rs28936
Entrez Id: 40
Gene Symbol: ASIC2
ASIC2
CUI: C0026769
Disease:
Multiple Sclerosis 		0.010 GeneticVariation BEFREE Application of these methods allowed us to find a significant association between MS and the SNP rs28936 located in the 3' UTR segment of ACCN1 with p = 0.0004 (p = 0.002, after adjusting for multiple testing). 17534430 2007