MIR122, microRNA 122, 406906

N. diseases: 250; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17669
rs17669
Entrez Id: 406906;100616357
Gene Symbol: MIR122;MIR3591
MIR122;MIR3591
CUI: C0038454
Disease:
Cerebrovascular accident 		0.010 GeneticVariation BEFREE Altogether, miR-122 rs17669 is a significant predictor for the risk of recurrent stroke, independent of traditional risk factors. 31811586 2020
dbSNP: rs17669
rs17669
Entrez Id: 406906;100616357
Gene Symbol: MIR122;MIR3591
MIR122;MIR3591
CUI: C0010346
Disease:
Crohn Disease 		0.010 GeneticVariation BEFREE In both diseases, rs17669 and rs11614913 (MIR122 and MIR196A2) seem to contribute to clinical phenotypes: ileal location in CD (odds ratio [OR] = 1.82, p = 0.03; OR = 0.51, p = 0.01), and left-sided extent in UC (OR = 0.43, p = 0.05; OR = 0.28, p = 0.002). 27718165 2017
dbSNP: rs17669
rs17669
Entrez Id: 406906;100616357
Gene Symbol: MIR122;MIR3591
MIR122;MIR3591
CUI: C0948008
Disease:
Ischemic stroke 		0.020 GeneticVariation BEFREE However, the three other miRNA (miR-143 rs4705342, miR-122 rs17669, and miR-124 r531564) were not associated with IS risk under allele or genotype, nor in different inheritance models. 30895838 2019
dbSNP: rs17669
rs17669
Entrez Id: 406906;100616357
Gene Symbol: MIR122;MIR3591
MIR122;MIR3591
CUI: C0948008
Disease:
Ischemic stroke 		0.020 GeneticVariation BEFREE Association of miRNA polymorphisms with prognosis outcomes was examined by the Kaplan-Meier method, log-rank test, and Cox proportional hazards models. miR-122 rs17669 was significantly associated with recurrence risk of ischemic stroke under the recessive model. 31811586 2020
dbSNP: rs1135519
rs1135519
Entrez Id: 406906;107985182
Gene Symbol: MIR122;LOC107985182
MIR122;LOC107985182
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE Our results suggest that SNP of rs1135519 modulates <i>miR-122</i> expression and contributes to the genetic susceptibility of HCC, either independently or together with rs9966765 in <i>miR-122.</i> Further well-designed studies with lager sample sizes are needed to confirm our findings. 30662901 2018
dbSNP: rs17669
rs17669
Entrez Id: 406906;100616357
Gene Symbol: MIR122;MIR3591
MIR122;MIR3591
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE Three selected SNPs in <i>miR-122</i> (rs9966765, rs1135519, and rs17669) were genotyped in 1050 HCC patients and 1079 cancer-free controls using Sequenom MassARRAY platform and the associations of the three SNPs and HCC risk were evaluated. 30662901 2018
dbSNP: rs9966765
rs9966765
Entrez Id: 406906;107985182
Gene Symbol: MIR122;LOC107985182
MIR122;LOC107985182
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE There was also a significant increased risk of HCC when combining risk genotypes of these loci, i.e., rs1135519 CC and rs9966765 CC. 30662901 2018
dbSNP: rs17669
rs17669
Entrez Id: 406906;100616357
Gene Symbol: MIR122;MIR3591
MIR122;MIR3591
CUI: C0009324
Disease:
Ulcerative Colitis 		0.010 GeneticVariation BEFREE In both diseases, rs17669 and rs11614913 (MIR122 and MIR196A2) seem to contribute to clinical phenotypes: ileal location in CD (odds ratio [OR] = 1.82, p = 0.03; OR = 0.51, p = 0.01), and left-sided extent in UC (OR = 0.43, p = 0.05; OR = 0.28, p = 0.002). 27718165 2017