rs1135519
|
MIR122;LOC107985182
|
Liver carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that SNP of rs1135519 modulates <i>miR-122</i> expression and contributes to the genetic susceptibility of HCC, either independently or together with rs9966765 in <i>miR-122.</i> Further well-designed studies with lager sample sizes are needed to confirm our findings.
|
30662901 |
2018 |
rs9966765
|
MIR122;LOC107985182
|
Liver carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
There was also a significant increased risk of HCC when combining risk genotypes of these loci, i.e., rs1135519 CC and rs9966765 CC.
|
30662901 |
2018 |
rs17669
|
MIR122;MIR3591
|
Ischemic stroke
|
|
0.020 |
GeneticVariation |
BEFREE |
However, the three other miRNA (miR-143 rs4705342, miR-122 rs17669, and miR-124 r531564) were not associated with IS risk under allele or genotype, nor in different inheritance models.
|
30895838 |
2019 |
rs17669
|
MIR122;MIR3591
|
Ischemic stroke
|
|
0.020 |
GeneticVariation |
BEFREE |
Association of miRNA polymorphisms with prognosis outcomes was examined by the Kaplan-Meier method, log-rank test, and Cox proportional hazards models. miR-122 rs17669 was significantly associated with recurrence risk of ischemic stroke under the recessive model.
|
31811586 |
2020 |
rs17669
|
MIR122;MIR3591
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In both diseases, rs17669 and rs11614913 (MIR122 and MIR196A2) seem to contribute to clinical phenotypes: ileal location in CD (odds ratio [OR] = 1.82, p = 0.03; OR = 0.51, p = 0.01), and left-sided extent in UC (OR = 0.43, p = 0.05; OR = 0.28, p = 0.002).
|
27718165 |
2017 |
rs17669
|
MIR122;MIR3591
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation |
BEFREE |
In both diseases, rs17669 and rs11614913 (MIR122 and MIR196A2) seem to contribute to clinical phenotypes: ileal location in CD (odds ratio [OR] = 1.82, p = 0.03; OR = 0.51, p = 0.01), and left-sided extent in UC (OR = 0.43, p = 0.05; OR = 0.28, p = 0.002).
|
27718165 |
2017 |
rs17669
|
MIR122;MIR3591
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation |
BEFREE |
Altogether, miR-122 rs17669 is a significant predictor for the risk of recurrent stroke, independent of traditional risk factors.
|
31811586 |
2020 |
rs17669
|
MIR122;MIR3591
|
Liver carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Three selected SNPs in <i>miR-122</i> (rs9966765, rs1135519, and rs17669) were genotyped in 1050 HCC patients and 1079 cancer-free controls using Sequenom MassARRAY platform and the associations of the three SNPs and HCC risk were evaluated.
|
30662901 |
2018 |