|
rs4636297
|
EGFL7;MIR126
|
Ischemic stroke
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to clarify whether genetic variations in four miRNA genes (miR-143 rs4705342, miR-122 rs17669, miR-126 rs4636297, and miR-124 rs531564) contribute to IS susceptibility.
|
30895838 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Ischemic stroke
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated whether three common microRNA polymorphisms (miR-21T>C [rs1292037], miR-126G>A [rs4636297] and miR-605T>C [rs2043556]) were associated with ischemic stroke (IS) risk in a Chinese population.
|
29221163 |
2017 |
|
rs1140713
|
EGFL7;MIR126
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) rs4636297 and rs1140713 of the <i>miR-126</i> gene were correlated with the Gensini score, serum BNP, LDL-C, cTnI, and serum vascular endothelial growth factor levels in patients with AMI (<i>p</i> < 0.05).
|
31184921 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) rs4636297 and rs1140713 of the <i>miR-126</i> gene were correlated with the Gensini score, serum BNP, LDL-C, cTnI, and serum vascular endothelial growth factor levels in patients with AMI (<i>p</i> < 0.05).
|
31184921 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Occlusive stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> Our study suggests that the miR-126 gene rs4636297 polymorphism may play an important role in the pathogenesis of small vessel occlusive stroke in the northern Chinese Han population.
|
30895838 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Cervical Intraepithelial Neoplasia
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that rs4636297</span> in miR-126 was associated with susceptibility to CIN and cervical cancer (<i>P</i>=0.019 and 0.019, respectively) and that the T allele was associated with a higher risk of CIN (<i>OR</i>=1.334, <i>95% CI</i>: 1.049-1.698) and cervical cancer (<i>OR</i>=1.296, <i>95% CI</i>: 1.044-1.609).
|
31598146 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that rs4636297</span> in miR-126 was associated with susceptibility to CIN and cervical cancer (<i>P</i>=0.019 and 0.019, respectively) and that the T allele was associated with a higher risk of CIN (<i>OR</i>=1.334, <i>95% CI</i>: 1.049-1.698) and cervical cancer (<i>OR</i>=1.296, <i>95% CI</i>: 1.044-1.609).
|
31598146 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
cervical cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that rs4636297</span> in miR-126 was associated with susceptibility to CIN and cervical cancer (<i>P</i>=0.019 and 0.019, respectively) and that the T allele was associated with a higher risk of CIN (<i>OR</i>=1.334, <i>95% CI</i>: 1.049-1.698) and cervical cancer (<i>OR</i>=1.296, <i>95% CI</i>: 1.044-1.609).
|
31598146 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> The miR-126 gene rs4636297 polymorphism was associated with decreased small vessel stroke risk (GA vs. GG: odds ratio (OR) = 0.62, <i>p</i> = .015; GA + AA vs. GG: OR = 0.637, <i>p</i> = .018; A vs. G: OR = 0.696, <i>p</i> = .033).
|
30895838 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that rs4636297</span> in miR-126 was associated with susceptibility to CIN and cervical cancer (<i>P</i>=0.019 and 0.019, respectively) and that the T allele was associated with a higher risk of CIN (<i>OR</i>=1.334, <i>95% CI</i>: 1.049-1.698) and cervical cancer (<i>OR</i>=1.296, <i>95% CI</i>: 1.044-1.609).
|
31598146 |
2019 |
|
rs4636297
|
EGFL7;MIR126
|
Endometriosis
|
|
0.010 |
GeneticVariation |
BEFREE |
These finding suggest that, for the first time, mir-126 rs4636297 and TGFβRI rs334348 polymorphisms may influence individual's susceptibility to endometriosis and its severity.
|
28277133 |
2017 |
|
rs4636297
|
EGFL7;MIR126
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
In an additive model, the A allele of rs4636297 SNP is significantly associated with STDR compared to people with none or mild diabetic retinopathy (DR) (odds ratio (OR) = 2.02, 95% confidence interval (CI) = 1.22-3.35, p = 0.006).
|
25616704 |
2015 |
|
rs4636297
|
EGFL7;MIR126
|
Visually threatening diabetic retinopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of rs4636297, known to be the non-functional allele for post-translational regulation of miR-126, is associated with STDR.
|
25616704 |
2015 |
|
rs4636297
|
EGFL7;MIR126
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, there was no association between SNP rs4636297 and survival time in NSCLC patients (P = 0.992).
|
22900072 |
2012 |
|
rs4636297
|
EGFL7;MIR126
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In our study, we analyzed two SNPs, rs4636297 within miR-126 and rs41272366 within miR-335, in three study populations for a putative association with breast cancer risk.
|
21046227 |
2011 |
|
rs4636297
|
EGFL7;MIR126
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
In our study, we analyzed two SNPs, rs4636297 within miR-126 and rs41272366 within miR-335, in three study populations for a putative association with breast cancer risk.
|
21046227 |
2011 |