MIR143, microRNA 143, 406935

N. diseases: 267; N. variants: 6
Disease: Malignant neoplasm of prostate ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4705343
rs4705343
Entrez Id: 406935;728264
Gene Symbol: MIR143;CARMN
MIR143;CARMN
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. 31423132 2019
dbSNP: rs4705342
rs4705342
Entrez Id: 406935;728264
Gene Symbol: MIR143;CARMN
MIR143;CARMN
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE In conclusion, our findings demonstrate that there is the significant association between the functional promoter variant rs4705342T>C in miR-143 and PCa risk and newly describe the miR-143-KLK2 interaction which provided another potential mechanism for miR-143 anti-tumor function. 25354797 2016