|
rs2910164
|
MIR146A;MIR3142HG
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma.
|
29127520 |
2018 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2910164 CG or GG genotype was associated with a significantly decreased risk for lung cancer compared to that of the CC genotype (adjusted odds ratio=0.80, 95% confidence interval=0.66-0.96, P=0.02).
|
24144839 |
2014 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation |
BEFREE |
We first investigated the association between the SNPs (rs2910164 G>C and rs3746444 T>C) in the pre-miRNA (hsa-mir-146a and hsa-mir-499) and RA in a Han Chinese population.
|
21181275 |
2011 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study suggested that the miR-196a2 gene rs11614913 polymorphism and the miR-146a gene rs2910164 polymorphism might associate with lung cancer risk.
|
25077922 |
2014 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, these results suggest that the miR-146a SNP rs2910164 may not be a risk factor for GCa in this Chinese population.
|
27105532 |
2016 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
There is no significant association between rs2910164 and rs11614913 and the risk of human gastric cancer.
|
26215064 |
2015 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast to these results, the same allelic variant of rs2910164 was found to confer an increased risk of developing lung cancer.
|
26337564 |
2015 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
miRNA 196a2(rs11614913) & 146a(rs2910164) polymorphisms & breast cancer risk for women in an Iranian population.
|
29965793 |
2018 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2910164/rs2292832/rs11614913 CTT and CCT haplotypes seems to have a protective role against GC (p = 0.002 and p = 0.001, respectively).
|
24379078 |
2014 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Conclusion Our data indicate that miR-146a (rs2910164</span>) and miR-27a (rs895819) variants contribute to breast cancer.
|
29521182 |
2018 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Over- or underexpression of miR-146a has been reported in several different human tumor types, and a polymorphism in its precursor form (pre-miR-146a rs2910164 G/C) has been recently studied in connection with cancer susceptibility.
|
23267167 |
2013 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, miR-146a rs2910164 GC is significantly associated with BC in the Pakistani population.
|
30963551 |
2019 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was found between rs2910164</span> and GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66-0.87; CC vs. GC+GG, OR = 0.84, 95% CI = 0.71-0.99; CC+GC vs. GG, OR = 0.82, 95% CI = 0.73-0.91) for the total data.
|
26202478 |
2017 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
However, limited evidence was found for association of miR-146a rs2910164 with cancer risk, and further well-designed studies with large sample size will be necessary to validate the effect of miR-146a rs2910164 on cancer susceptibility.
|
22952151 |
2012 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 are risk factors for cancer development, whereas mir-149 rs2292832 and miR-27a rs895919 are not associated with cancer risk.
|
24278149 |
2013 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Liver carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that rs2910164 in miR-146a may confer susceptibility to HCC, especially in the Chinese population.
|
25108400 |
2014 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to examine the associations of the miR-146a G/C (rs2910164) and TLR4 +3725 G/C (rs11536889) polymorphisms with the risk of Helicobacter pylori (H. pylori) infection, gastric atrophy, and gastric cancer in a Japanese population.
|
20721625 |
2011 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 are risk factors for cancer development, whereas mir-149 rs2292832 and miR-27a rs895919 are not associated with cancer risk.
|
24278149 |
2013 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, miR-146a rs2910164 polymorphism may influence susceptibility to lung cancer in Chinese nonsmoking females through targeting TRAF6.
|
27911870 |
2017 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested.
|
20640596 |
2011 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer.
|
26345790 |
2015 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer.
|
22719192 |
2012 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
However, for the miR-146a rs2910164 (G>C), miR-149 rs2292832 (G>T), miR-373 rs12983273 (C>T), and miR-423 rs6505162 (C>A) polymorphisms, we failed to find any significant association with the risk of breast cancer in any genetic model.
|
23982873 |
2014 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent evidence suggests that the rs2910164 variant of miR-146a is associated with the development of certain types of cancer.
|
23898084 |
2013 |
|
rs2910164
|
MIR146A;MIR3142HG
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
This study investigated the influence of the miR-146a GC rs2910164 on miR-146a expression in young South African Indians with CAD.
|
23794009 |
2014 |