|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
The results demonstrated that miR-196a2 rs11614913 was significantly associated with a decreased cancer risk, in particular with a decreased risk for colorectal cancer and gastric cancer, or for Asian population subgroup.
|
29371991 |
2017 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
By logistic regression analysis, we found that the CC genotype of rs11614913</span> was associated with an increased risk of gastric cancer</span> in a codominant model (OR = 2.68, 95%CI = 1.17-6.44).
|
27173281 |
2016 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer.
|
26345790 |
2015 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
There is no significant association between rs2910164 and rs11614913 and the risk of human gastric cancer.
|
26215064 |
2015 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
Our studies suggested that the miR-146a rs2910164 polymorphism might marginally contribute to a decreased risk of gastric cancer, especially in Caucasians, whereas the miR-196a2 rs11614913 polymorphism might not be associated with susceptibility to GC.
|
26406571 |
2015 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2910164/rs2292832/rs11614913</span> CTT and CCT haplotypes seems to have a protective role against GC (p = 0.002 and p = 0.001, respectively).
|
24379078 |
2014 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs11614913 (T>C), rs2910164 (C>T), and rs3746444 (A>G) SNPs were genotyped in 130 advanced GCs performing chemotherapy.
|
25202115 |
2014 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs11614913 and rs2910164 do not pose general cancer risk, but rs11614913 may influence gastric cancer in Japanese elderly population.
|
24716941 |
2014 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed the correlations of rs11614913 polymorphism with gastric cancer susceptibility in test and validation sets.
|
23423813 |
2013 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.
|
21073609 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphism of miR-196a-2 (rs11614913) and risk of gastric cancer, a hospital-based case-control study was conducted in a Chinese population.
|
19834808 |
2010 |
|
rs12304647
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether the potential functional SNPs in MIR196A2 promoter had effect on the susceptibility to gastric cancer (GC) in a Chinese population.We conducted a 2-stage case-control study (753 cases and 854 controls in testing set; 940 cases and 1061 controls in validation set) to evaluate the association between 2 potential functional SNPs in MIR196A2 promoter (rs12304647 A>C and rs35010275 G>C) and GC risk.
|
25474430 |
2014 |
|
rs35010275
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, each allele of rs35010275 displayed completely opposite effects to influence the transcription activity of MIR196A2 promoter via recruiting different transcription factors or complexes.The functional rs35010275 G>C polymorphism in MIR196A2 promoter was significantly associated with miR-196a expression and influenced the genetic susceptibility to GC.
|
25474430 |
2014 |