MBL2, mannose binding lectin 2, 4153

N. diseases: 563; N. variants: 21
Disease: HIV-1 infection ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800451
rs1800451
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C2363741
Disease:
HIV-1 infection 		0.010 GeneticVariation BEFREE We found that (i) the prevalence of the common variant MBL alleles is correlated with the incidence of tuberculosis in sub-Saharan Africa (r=0.565), (ii) the mutant MBL G57E allele, in either the homozygous or compound heterozygous state, is associated with susceptibility to HIV-1 infection in the Gabonese population (P=0.019).Our data plus those in the literature suggest that individuals who are homozygous for the mutant MBL alleles display increased susceptibility to infections. 12847552 2003