MDM4, MDM4 regulator of p53, 4194

N. diseases: 265; N. variants: 9
Disease: Malignant neoplasm of breast ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4245739
rs4245739
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.730 GeneticVariation BEFREE However, our study failed to show any relationship between rs4245739 A>C and rs11801299 G>A variants and BC risk (P > .05). 29439926 2018
dbSNP: rs4245739
rs4245739
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.730 GeneticVariation BEFREE Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs. 29372105 2017
dbSNP: rs4245739
rs4245739
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.730 GeneticVariation GWASDB Genome-wide association studies identify four ER negative-specific breast cancer risk loci. 23535733 2013
dbSNP: rs4245739
rs4245739
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.730 GeneticVariation BEFREE Interestingly, we observed a combinational effect between MDM4 rs4245739 and P53 Arg72Pro variants in attenuating breast cancer risk, highlighting the importance of the P53 tumor suppressor pathway genes during malignant transformation. 23793604 2013
dbSNP: rs1380576
rs1380576
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE Our findings proposed that the MDM4 rs1380576 C>G polymorphism was a protective factor for BC risk in our population. 29439926 2018
dbSNP: rs2290854
rs2290854
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 × 10(-8), HR = 1.14, 95% CI: 1.09-1.20). 23544013 2013
dbSNP: rs116197192
rs116197192
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE The D153G substitution only partially segregated with breast cancer in the family and was not identified on additional 680 chromosomes screened. 18279506 2008