MDM4, MDM4 regulator of p53, 4194

N. diseases: 265; N. variants: 9
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4245739
rs4245739
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.720 GeneticVariation BEFREE This study is the first, to our knowledge, to demonstrate regulation of the MDM4 rs4245739 SNP C-allele by two miRNAs in prostate cancer, and thereby to identify a mechanism by which the MDM4 rs4245739 SNP A-allele may be associated with an increased risk for prostate cancer. 25670033 2015
dbSNP: rs4245739
rs4245739
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.720 GeneticVariation BEFREE MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk. 26471763 2015
dbSNP: rs4245739
rs4245739
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0376358
Disease:
Malignant neoplasm of prostate
A 0.720 GeneticVariation GWASDB Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. 23535732 2013
dbSNP: rs1380576
rs1380576
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.010 GeneticVariation BEFREE Both the Mdm4 and Hausp SNPs (rs1380576 and rs1529916) were found to be associated with higher D'Amico risk prostate cancer category at the time of diagnosis (P = 0.023 and P = 0.046, respectively). 20855462 2010