DisGeNET - a database of gene-disease associations

MET, MET proto-oncogene, receptor tyrosine kinase, 4233

N. diseases: 90; N. variants: 28

Source: CURATED ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs38855

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0202236
Disease:

Triglycerides measurement

0.800

GeneticVariation

GWASCAT

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

28334899

2017

dbSNP:

rs38855

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0202236
Disease:

Triglycerides measurement

0.800

GeneticVariation

GWASDB

Discovery and refinement of loci associated with lipid levels.

24097068

2013

dbSNP:

rs38855

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0202236
Disease:

Triglycerides measurement

0.800

GeneticVariation

GWASCAT

Discovery and refinement of loci associated with lipid levels.

24097068

2013

dbSNP:

rs794728016

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C4084709
Disease:

DEAFNESS, AUTOSOMAL RECESSIVE 97

0.800

GeneticVariation

UNIPROT

dbSNP:

rs794728016

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C4084709
Disease:

DEAFNESS, AUTOSOMAL RECESSIVE 97

0.800

CausalMutation

CLINVAR

dbSNP:

rs34589476

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0027651
Disease:

Neoplasms

0.730

GeneticVariation

CLINVAR

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.

17483355

2007

dbSNP:

rs56391007

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0027651
Disease:

Neoplasms

0.720

GeneticVariation

CLINVAR

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.

17483355

2007

dbSNP:

rs1057519824

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0027651
Disease:

Neoplasms

0.710

GeneticVariation

CLINVAR

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.

17483355

2007

dbSNP:

rs121913246

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0027651
Disease:

Neoplasms

0.710

GeneticVariation

CLINVAR

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.

17483355

2007

dbSNP:

rs1476454

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C0023508
Disease:

White Blood Cell Count procedure

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs1858830

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C2985280
Disease:

Blood Protein Measurement

0.700

GeneticVariation

GWASCAT

Co-regulatory networks of human serum proteins link genetics to disease.

30072576

2018

dbSNP:

rs41741

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1278049
Disease:

Serum gamma-glutamyl transferase measurement

0.700

GeneticVariation

GWASCAT

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

29403010

2018

dbSNP:

rs121913243

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1336839
Disease:

Type 1 Papillary Renal Cell Carcinoma

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs121913246

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1336839
Disease:

Type 1 Papillary Renal Cell Carcinoma

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs121913668

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1336839
Disease:

Type 1 Papillary Renal Cell Carcinoma

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs121913669

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1336839
Disease:

Type 1 Papillary Renal Cell Carcinoma

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs121913670

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1336839
Disease:

Type 1 Papillary Renal Cell Carcinoma

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs121913673

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1336839
Disease:

Type 1 Papillary Renal Cell Carcinoma

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs794728016

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C3874334
Disease:

Severe hearing loss

0.700

CausalMutation

CLINVAR

A mutation of MET, encoding hepatocyte growth factor receptor, is associated with human DFNB97 hearing loss.

25941349

2015

dbSNP:

rs121913243

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1378703
Disease:

Renal carcinoma

0.700

GeneticVariation

CLINVAR

Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

25157968

2014

dbSNP:

rs121913244

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1378703
Disease:

Renal carcinoma

0.700

GeneticVariation

CLINVAR

Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

25157968

2014

dbSNP:

rs121913245

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1378703
Disease:

Renal carcinoma

0.700

GeneticVariation

CLINVAR

Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

25157968

2014

dbSNP:

rs121913246

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1378703
Disease:

Renal carcinoma

0.700

GeneticVariation

CLINVAR

Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

25157968

2014

dbSNP:

rs121913243

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1336839
Disease:

Type 1 Papillary Renal Cell Carcinoma

0.700

GeneticVariation

UNIPROT

Canadian guideline on genetic screening for hereditary renal cell cancers.

24319509

2013

dbSNP:

rs121913243

Entrez Id:	4233
Gene Symbol:	MET

MET

CUI:	C1378703
Disease:

Renal carcinoma

0.700

GeneticVariation

CLINVAR

Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.

23213094

2013