MGMT, O-6-methylguanine-DNA methyltransferase, 4255

N. diseases: 444; N. variants: 24
Disease: Carcinoma of lung ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12917
rs12917
Entrez Id: 4255;105378560
Gene Symbol: MGMT;LOC105378560
MGMT;LOC105378560
CUI: C0684249
Disease:
Carcinoma of lung 		0.030 GeneticVariation BEFREE Our results showed that MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of LC. 30785779 2019
dbSNP: rs12917
rs12917
Entrez Id: 4255;105378560
Gene Symbol: MGMT;LOC105378560
MGMT;LOC105378560
CUI: C0684249
Disease:
Carcinoma of lung 		0.030 GeneticVariation BEFREE This meta-analysis suggests that the MGMT Leu84Phe polymorphisms are associated with lung cancer risk among Caucasians not in Asians. 24390665 2014
dbSNP: rs12917
rs12917
Entrez Id: 4255;105378560
Gene Symbol: MGMT;LOC105378560
MGMT;LOC105378560
CUI: C0684249
Disease:
Carcinoma of lung 		0.030 GeneticVariation BEFREE In further stratified analyses for the Leu84Phe and Ile143Val polymorphisms, the increased risk of cancer remained in subgroups of Caucasians, patients with esophageal cancer for the Leu84Phe polymorphism, and patients with lung cancer for the Ile143Val polymorphism. 23760981 2013
dbSNP: rs2308321
rs2308321
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0684249
Disease:
Carcinoma of lung 		0.010 GeneticVariation BEFREE In further stratified analyses for the Leu84Phe and Ile143Val polymorphisms, the increased risk of cancer remained in subgroups of Caucasians, patients with esophageal cancer for the Leu84Phe polymorphism, and patients with lung cancer for the Ile143Val polymorphism. 23760981 2013
dbSNP: rs12268840
rs12268840
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0684249
Disease:
Carcinoma of lung 		0.010 GeneticVariation BEFREE There was no evidence of an association between rs12268840 and lung cancer risk. 17957803 2008