Moreover, carriers of at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs738792 were likely to progress to Child-Pugh B or C grade, while individuals with at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs28382575 were at higher risk of developing stage III/IV disease, large tumors or lymph node metastasis.
Furthermore, among patients with OSCC with betel nut consumption, those who have at least one polymorphic C allele of MMP-11 rs738792 have an increased incidence of lymph node metastasis when compared with those patients homozygous for T/T.
Five single-nucleotide polymorphisms (SNPs) of the MMP-11 gene rs738791, rs738792, rs2267029, rs28382575, and rs131451 from one hundred and thirty patients with invasive cancer, 99 patients with high-grade cervical intraepithelial neoplasia (CIN) of uterine and 335 normal controls were analyzed using real-time polymerase chain reaction.
Five single-nucleotide polymorphisms (SNPs) of the MMP-11 gene rs738791, rs738792, rs2267029, rs28382575, and rs131451 from one hundred and thirty patients with invasive cancer, 99 patients with high-grade cervical intraepithelial neoplasia (CIN) of uterine and 335 normal controls were analyzed using real-time polymerase chain reaction.
Although CT/TT genotype of MMP-11 gene rs738791 tended to increase the risk of developing stage II disease at least (p=0.035; OR: 2.16, 95% CI: 1.05-4.44) and deep stromal invasion more than 10 mm (p=0.043; OR: 2.08, 95% CI: 1.02-4.26) with CC as a reference in patients with uterine cervical cancer.
Our results revealed that genotypic frequencies of CT/TT in MMP-11 SNP rs738791, with CC as a reference, tended to exhibit significantly different distributions (p=0.044, AOR: 0.63, 95% CI: 0.41-0.99) between patients with cervical invasive cancer and normal control women when controlling age.
Here, we report on the association between five single nucleotide polymorphisms (SNPs) - rs738791, rs2267029, rs738792, rs28382575, and rs131451 - of the <i>MMP-11</i> gene and HCC susceptibility, as well as clinical outcomes, in 293 patients with HCC and in 586 cancer-free controls.
Moreover, carriers of at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs738792 were likely to progress to Child-Pugh B or C grade, while individuals with at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs28382575 were at higher risk of developing stage III/IV disease, large tumors or lymph node metastasis.
Moreover, carriers of at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs738792 were likely to progress to Child-Pugh B or C grade, while individuals with at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs28382575 were at higher risk of developing stage III/IV disease, large tumors or lymph node metastasis.
Moreover, carriers of at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs738792 were likely to progress to Child-Pugh B or C grade, while individuals with at least one C allele (C/T+C/C genotype) at the <i>MMP-11</i> SNP rs28382575 were at higher risk of developing stage III/IV disease, large tumors or lymph node metastasis.
Initial findings indicated that the best p values for each trait were 0.02 for myopia at rs2274755 (MMP9), 0.02 for SE at both rs3740938 (MMP8) and rs131451 (MMP11), 0.01 for axial length at rs11225395 (MMP8), 0.01 for anterior chamber depth at rs498186 (MMP1) and 0.02 at rs10488 (MMP1).
The SNP (rs738792) showed a statistically significant association with KD in the codominant (OR=1.61, 95% CI=1.11-2.34, P=0.011) and dominant (OR=1.92, 95% CI=1.21-3.06, P=0.006) models.