MTHFR, methylenetetrahydrofolate reductase, 4524

N. diseases: 985; N. variants: 137
Disease: Bipolar Disorder ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia. 25101272 2014
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE We were unable to confirm an association between bipolar disorder and C677T polymorphism (rs1801133) of the MTHFR gene, as suggested in some previous studies. 24577139 2014
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE The random effect pooled OR was also significant and shows meager association between MTHFR C677T genotype and bipolar disorder. 21955385 2011
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD. 20552676 2010
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE In conclusion, the MTHFR C677T variant is unlikely to play a major role in the susceptibility to bipolar disorder, although MTHFR plays an important role in the one-carbon metabolism and DNA methylation. 18983889 2009
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. 18165967 2008
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. 18513846 2008
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.080 GeneticVariation BEFREE Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia. 16545905 2006
dbSNP: rs397507444
rs397507444
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.030 GeneticVariation BEFREE We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. 18513846 2008
dbSNP: rs397507444
rs397507444
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.030 GeneticVariation BEFREE Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. 18165967 2008
dbSNP: rs397507444
rs397507444
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.030 GeneticVariation BEFREE Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia. 17188847 2007
dbSNP: rs1801133
rs1801133
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.020 GeneticVariation BEFREE We were unable to confirm an association between bipolar disorder and C677T polymorphism (rs1801133) of the MTHFR gene, as suggested in some previous studies. 24577139 2014
dbSNP: rs1801133
rs1801133
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.020 GeneticVariation BEFREE We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. 18513846 2008
dbSNP: rs1194897557
rs1194897557
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.010 GeneticVariation BEFREE These results are the first suggesting a possible association between T833C polymorphism (rs5742905) of the CBS gene and bipolar disorder. 24577139 2014
dbSNP: rs1801131
rs1801131
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0005586
Disease:
Bipolar Disorder 		0.010 GeneticVariation BEFREE We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. 18513846 2008