In the present case-control study, we evaluated the association between three SNPs at nt -123 (A or C, rs17000900), nt -88 (G or T, rs2071430), and nt +20 (A or C, rs464138) and MS risk as well as treatment response in a population of Iranian MS patients including 146 IFNβ responders and 85 non-responders as well as 180 healthy controls.
The objective of this study was to evaluate the associations between two MXA promoter region single nucleotide polymorphisms (rs2071430 and rs17000900) and the gene expression responses, clinical and MRI phenotypes in IFN-beta treated MS patients.
Patients with MxA rs2071430 TT genotype were more likely to develop HCV infection chronicity (additive model: odds ratio (OR) 1.22, 95% confidence interval (CI) 1.01-1.48, P = 0.042).
In the present case-control study, we evaluated the association between three SNPs at nt -123 (A or C, rs17000900), nt -88 (G or T, rs2071430), and nt +20 (A or C, rs464138) and MS risk as well as treatment response in a population of Iranian MS patients including 146 IFNβ responders and 85 non-responders as well as 180 healthy controls.
In the present case-control study, we evaluated the association between three SNPs at nt -123 (A or C, rs17000900), nt -88 (G or T, rs2071430), and nt +20 (A or C, rs464138) and MS risk as well as treatment response in a population of Iranian MS patients including 146 IFNβ responders and 85 non-responders as well as 180 healthy controls.
The carriers of minor alleles of five MxA SNPs, including rs457274, rs2071430 (MxA -88), rs461093, rs469083, and rs1557372, were associated with faster cognitive decline over 2 years.
The carriers of minor alleles of five MxA SNPs, including rs457274, rs2071430 (MxA -88), rs461093, rs469083, and rs1557372, were associated with faster cognitive decline over 2 years.
The carriers of minor alleles of five MxA SNPs, including rs457274, rs2071430 (MxA -88), rs461093, rs469083, and rs1557372, were associated with faster cognitive decline over 2 years.
The carriers of minor alleles of five MxA SNPs, including rs457274, rs2071430 (MxA -88), rs461093, rs469083, and rs1557372, were associated with faster cognitive decline over 2 years.
The carriers of minor alleles of five MxA SNPs, including rs457274, rs2071430 (MxA -88), rs461093, rs469083, and rs1557372, were associated with faster cognitive decline over 2 years.
The carriers of minor alleles of five MxA SNPs, including rs457274, rs2071430 (MxA -88), rs461093, rs469083, and rs1557372, were associated with faster cognitive decline over 2 years.
The association with the susceptibility to HBV infection was only observed for IL10RB K47E when we compared the individuals with persistent HBV infection through nonmaternal transmission to the controls with asymptomatic self-limited HBV infection.