NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Disease: Noonan Syndrome ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs267606921
rs267606921
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.700 CausalMutation CLINVAR Recently, two mutations in NRAS were reported to be associated with Noonan syndrome, T50I and G60E. 21263000 2011
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		T 0.700 CausalMutation CLINVAR A restricted spectrum of NRAS mutations causes Noonan syndrome. 19966803 2010
dbSNP: rs267606921
rs267606921
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.700 CausalMutation CLINVAR A restricted spectrum of NRAS mutations causes Noonan syndrome. 19966803 2010
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.700 CausalMutation CLINVAR RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. 18952898 2009
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		T 0.700 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918 2009
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		T 0.700 CausalMutation CLINVAR Hyperactive Ras in developmental disorders and cancer. 17384584 2007
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		T 0.700 CausalMutation CLINVAR Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. 16518851 2006
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.700 CausalMutation CLINVAR Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse. 15831708 2005
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.700 CausalMutation CLINVAR Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. 14982869 2004
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.700 CausalMutation CLINVAR Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. 15046639 2004
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		T 0.700 CausalMutation CLINVAR Juvenile myelomonocytic leukemia and Noonan syndrome. 10598665 2000
dbSNP: rs267606920
rs267606920
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0028326
Disease:
Noonan Syndrome 		0.010 GeneticVariation BEFREE The c.179G>A (p.G60E) mutation was identified in two patients with typical NS, confirming that NRAS germline mutations are a rare cause of this syndrome. 22887781 2012