DisGeNET - a database of gene-disease associations

NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17

Disease: Juvenile Myelomonocytic Leukemia ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs121434596

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

GeneticVariation

UNIPROT

American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.

24493721

2014

dbSNP:

rs121913237

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

GeneticVariation

UNIPROT

American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.

24493721

2014

dbSNP:

rs121434596

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

GeneticVariation

BEFREE

We report the case of a child with a diagnosis of JMML carrying two mutations of NRAS gene (c.37G>C and c.38G>A) independently occurring in long-term culture initiating cells.

22183880

2012

dbSNP:

rs121913237

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

GeneticVariation

BEFREE

In the present study, we report 2 patients with somatic mosaicism for oncogenic NRAS mutations (G12D and G12S) associated with the development of JMML.

22753870

2012

dbSNP:

rs121434596

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

GeneticVariation

UNIPROT

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

17332249

2007

dbSNP:

rs121913237

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

GeneticVariation

UNIPROT

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

17332249

2007

dbSNP:

rs121434596

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

CausalMutation

CLINVAR

dbSNP:

rs121913237

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.810

CausalMutation

CLINVAR

dbSNP:

rs121913250

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.710

GeneticVariation

BEFREE

In the present study, we report 2 patients with somatic mosaicism for oncogenic NRAS mutations (G12D and G12S) associated with the development of JMML.

22753870

2012

dbSNP:

rs121913250

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.710

CausalMutation

CLINVAR

A restricted spectrum of NRAS mutations causes Noonan syndrome.

19966803

2010

dbSNP:

rs121913250

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.710

CausalMutation

CLINVAR

Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia.

19047918

2009

dbSNP:

rs121913250

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.710

CausalMutation

CLINVAR

Hyperactive Ras in developmental disorders and cancer.

17384584

2007

dbSNP:

rs121913250

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.710

CausalMutation

CLINVAR

Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.

16518851

2006

dbSNP:

rs121913250

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.710

CausalMutation

CLINVAR

Juvenile myelomonocytic leukemia and Noonan syndrome.

10598665

2000

dbSNP:

rs1057519695

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.010

GeneticVariation

BEFREE

Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia.

27145535

2016

dbSNP:

rs1057519834

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.010

GeneticVariation

BEFREE

Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia.

27145535

2016

dbSNP:

rs11554290

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.010

GeneticVariation

BEFREE

Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia.

27145535

2016

dbSNP:

rs121434595

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

CUI:	C0349639
Disease:

Juvenile Myelomonocytic Leukemia

0.010

GeneticVariation

BEFREE

We report the case of a child with a diagnosis of JMML carrying two mutations of NRAS gene (c.37G>C and c.38G>A) independently occurring in long-term culture initiating cells.

22183880

2012