NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 67; N. variants: 16
Source: CURATED ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia 		0.810 GeneticVariation UNIPROT American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers. 24493721 2014
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia 		0.810 GeneticVariation UNIPROT American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers. 24493721 2014
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia 		0.810 GeneticVariation UNIPROT Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia 		0.810 GeneticVariation UNIPROT Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia 		T 0.810 CausalMutation CLINVAR
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia 		T 0.810 CausalMutation CLINVAR
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CA 0.800 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs1057519834
rs1057519834
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CT 0.800 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs11554290
rs11554290
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.800 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs11554290
rs11554290
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		C 0.800 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs11554290
rs11554290
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.800 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs8453
rs8453
Entrez Id: 4893;7812
Gene Symbol: NRAS;CSDE1
NRAS;CSDE1
CUI: C0004352
Disease:
Autistic Disorder 		G 0.800 GeneticVariation GWASCAT Common genetic variants on 1p13.2 associate with risk of autism. 24189344 2014
dbSNP: rs8453
rs8453
Entrez Id: 4893;7812
Gene Symbol: NRAS;CSDE1
NRAS;CSDE1
CUI: C0004352
Disease:
Autistic Disorder 		G 0.800 GeneticVariation GWASDB Common genetic variants on 1p13.2 associate with risk of autism. 24189344 2014
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CA 0.800 CausalMutation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304 2013
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CA 0.800 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CC 0.800 CausalMutation CLINVAR Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. 23538902 2013
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CA 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898 2013
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CC 0.800 CausalMutation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304 2013
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CC 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898 2013
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CC 0.800 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs1057519695
rs1057519695
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		CA 0.800 CausalMutation CLINVAR Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. 23538902 2013
dbSNP: rs11554290
rs11554290
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.800 CausalMutation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304 2013
dbSNP: rs11554290
rs11554290
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		C 0.800 CausalMutation CLINVAR Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. 23538902 2013
dbSNP: rs11554290
rs11554290
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.800 CausalMutation CLINVAR Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. 23538902 2013
dbSNP: rs11554290
rs11554290
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898 2013