OAS1, 2'-5'-oligoadenylate synthetase 1, 4938

N. diseases: 72; N. variants: 11
Disease: Diabetes Mellitus, Insulin-Dependent ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10774671
rs10774671
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent 		0.030 GeneticVariation BEFREE The data suggest that there may be a weak association with T1D for two OAS1 polymorphisms, rs3741981 and rs10774671, in populations of European descent. 19956105 2009
dbSNP: rs10774671
rs10774671
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent 		0.030 GeneticVariation BEFREE Recently, it was reported that an A/G splice-site single nucleotide polymorphism (SNP; rs10774671) in the OAS1 gene, encoding 2'5'-oligoadenylate synthetase, was associated with a protective effect against type 1 diabetes in unaffected siblings, and yet affected siblings showed random transmission. 16644715 2006
dbSNP: rs10774671
rs10774671
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent 		0.030 GeneticVariation BEFREE We confirm the T1D association with rs10774671, but we conclude that it cannot be attributed (solely) to the splicing variant rs10774671. 16014697 2006