OAS1, 2'-5'-oligoadenylate synthetase 1, 4938

N. diseases: 72; N. variants: 11
Disease: Multiple Sclerosis ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10774671
rs10774671
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
CUI: C0026769
Disease:
Multiple Sclerosis 		0.010 GeneticVariation BEFREE No association was found between rs10774671 and MS. As the two SNPs are in linkage disequilibrium in Europeans, the previously reported association between rs10774671 and MS susceptibility might be driven by rs11352835, possibly explaining the contrasting results previously observed for the splice-site polymorphism. 21735172 2012
dbSNP: rs11352835
rs11352835
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
CUI: C0026769
Disease:
Multiple Sclerosis 		0.010 GeneticVariation BEFREE A case/control study for MS indicated that rs11352835</span> is associated with disease susceptibility (for an allelic model with the deleted allele predisposing to MS, OR 1.27, 95% CI 1.072-1.513, p = 0.010). 21735172 2012