|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Carcinogenesis
|
|
0.020 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Carcinogenesis
|
|
0.020 |
GeneticVariation |
BEFREE |
Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
|
25583987 |
2015 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Myeloid Leukemia, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Leukemogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
|
rs1483790387
|
TMED7;TMED7-TICAM2
|
Leukemogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
|
rs1483790387
|
TMED7;TMED7-TICAM2
|
Myeloid Leukemia, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
|
rs776977530
|
TMED7;TMED7-TICAM2
|
Squamous cell carcinoma of the head and neck
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms increases risk of SPM in patients with index SCCHN.
|
22449259 |
2012 |
|
rs776977530
|
TMED7;TMED7-TICAM2
|
SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms increases risk of SPM in patients with index SCCHN.
|
22449259 |
2012 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Agenesis of corpus callosum
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we transfected nondegradable p27 mutant (T187A) and wild-type gene into A</span>CC cell line.
|
17431674 |
2007 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Aplasia Cutis Congenita
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we transfected nondegradable p27 mutant (T187A) and wild-type gene into A</span>CC cell line.
|
17431674 |
2007 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Transduction of p27(T187A) in breast cancer cells with a doxycycline-regulated adenovirus led to greater inhibition of proliferation, more extensive apoptosis, with a markedly reduced protein levels of cyclin E and increased accumulation of cyclin D1, compared with wild-type p27.
|
15996662 |
2005 |
|
rs1250394819
|
TMED7;TMED7-TICAM2;LOC101927100
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Transduction of p27(T187A) in breast cancer cells with a doxycycline-regulated adenovirus led to greater inhibition of proliferation, more extensive apoptosis, with a markedly reduced protein levels of cyclin E and increased accumulation of cyclin D1, compared with wild-type p27.
|
15996662 |
2005 |