|
rs61658003
|
GP6;LOC107985325
|
Finding of Mean Corpuscular Hemoglobin
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1654425
|
GP6;LOC107985325
|
Blood Protein Measurement
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
rs1613662
|
GP6;LOC107985325
|
Platelet mean volume determination (procedure)
|
A |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs1613662
|
GP6;LOC107985325
|
Platelet Component Distribution Width Measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs1671152
|
GP6;LOC107985325
|
Reticulocyte count (procedure)
|
G |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs1671152
|
GP6;LOC107985325
|
Platelet aggregation
|
T |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
|
20526338 |
2010 |
|
rs199588110
|
GP6;LOC107985325
|
Glycoprotein VI deficiency
|
|
0.700 |
GeneticVariation |
UNIPROT |
A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder.
|
19552682 |
2009 |
|
rs199588110
|
GP6;LOC107985325
|
Glycoprotein VI deficiency
|
|
0.700 |
GeneticVariation |
UNIPROT |
Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.
|
19549989 |
2009 |
|
rs387906919
|
GP6;LOC107985325
|
Glycoprotein VI deficiency
|
|
0.700 |
GeneticVariation |
UNIPROT |
Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.
|
19549989 |
2009 |
|
rs387906919
|
GP6;LOC107985325
|
Glycoprotein VI deficiency
|
|
0.700 |
GeneticVariation |
UNIPROT |
A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder.
|
19552682 |
2009 |
|
rs1613662
|
GP6;LOC107985325
|
Venous Thromboembolism
|
|
0.030 |
GeneticVariation |
BEFREE |
Rs9574, rs1049636, rs2227589 and rs1613662 polymorphisms might be risk factors of VTE.
|
28353616 |
2017 |
|
rs1613662
|
GP6;LOC107985325
|
Venous Thromboembolism
|
|
0.030 |
GeneticVariation |
BEFREE |
We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes.
|
23150947 |
2013 |
|
rs1613662
|
GP6;LOC107985325
|
Venous Thromboembolism
|
|
0.030 |
GeneticVariation |
BEFREE |
However, using this large cohort of subjects, we were able to replicate the mild effects of 2 nonsynonymous SNPs, rs1613662 in GP6 and rs13146272 in CYP4V2, recently suspected to be associated with VTE.
|
19278955 |
2009 |
|
rs1654416
|
GP6;LOC107985325
|
Stiff-Person Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analysis showed association of the minor alleles with the SPS manifested by fetal loss as follows-rs1671152 (odds ratio [OR]: 4.667, 95% confidence interval [CI]: 1.462-14.89, P = .006), rs2304167 (OR: 5.085, 95% CI: 1.605-16.10, P = .003), and rs1654416 (OR: 5.085, 95% CI: 1.605-16.10, P = .003).
|
28041267 |
2018 |
|
rs1654416
|
GP6;LOC107985325
|
SMALL PATELLA SYNDROME
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analysis showed association of the minor alleles with the SPS manifested by fetal loss as follows-rs1671152 (odds ratio [OR]: 4.667, 95% confidence interval [CI]: 1.462-14.89, P = .006), rs2304167 (OR: 5.085, 95% CI: 1.605-16.10, P = .003), and rs1654416 (OR: 5.085, 95% CI: 1.605-16.10, P = .003).
|
28041267 |
2018 |
|
rs1671152
|
GP6;LOC107985325
|
Stiff-Person Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analysis showed association of the minor alleles with the SPS manifested by fetal loss as follows-rs1671152 (odds ratio [OR]: 4.667, 95% confidence interval [CI]: 1.462-14.89, P = .006), rs2304167 (OR: 5.085, 95% CI: 1.605-16.10, P = .003), and rs1654416 (OR: 5.085, 95% CI: 1.605-16.10, P = .003).
|
28041267 |
2018 |
|
rs1671152
|
GP6;LOC107985325
|
SMALL PATELLA SYNDROME
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analysis showed association of the minor alleles with the SPS manifested by fetal loss as follows-rs1671152 (odds ratio [OR]: 4.667, 95% confidence interval [CI]: 1.462-14.89, P = .006), rs2304167 (OR: 5.085, 95% CI: 1.605-16.10, P = .003), and rs1654416 (OR: 5.085, 95% CI: 1.605-16.10, P = .003).
|
28041267 |
2018 |
|
rs2304167
|
GP6;LOC107985325
|
Stiff-Person Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analysis showed association of the minor alleles with the SPS manifested by fetal loss as follows-rs1671152 (odds ratio [OR]: 4.667, 95% confidence interval [CI]: 1.462-14.89, P = .006), rs2304167 (OR: 5.085, 95% CI: 1.605-16.10, P = .003), and rs1654416 (OR: 5.085, 95% CI: 1.605-16.10, P = .003).
|
28041267 |
2018 |
|
rs2304167
|
GP6;LOC107985325
|
SMALL PATELLA SYNDROME
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analysis showed association of the minor alleles with the SPS manifested by fetal loss as follows-rs1671152 (odds ratio [OR]: 4.667, 95% confidence interval [CI]: 1.462-14.89, P = .006), rs2304167 (OR: 5.085, 95% CI: 1.605-16.10, P = .003), and rs1654416 (OR: 5.085, 95% CI: 1.605-16.10, P = .003).
|
28041267 |
2018 |
|
rs1671152
|
GP6;LOC107985325
|
Miscarriage
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a higher occurrence of three SNPs in patients with platelet hyperaggregability and history of miscarriage (rs1671152, rs1654433, rs1671215).
|
26308704 |
2015 |
|
rs1613662
|
GP6;LOC107985325
|
Miscarriage
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that variants of GP6 SNPs, namely, rs1671153, rs1654410, rs1654419, and rs1613662, may be associated with risk of recurrent miscarriage.
|
25086789 |
2014 |
|
rs12610286
|
GP6;LOC107985325
|
SMALL PATELLA SYNDROME
|
|
0.010 |
GeneticVariation |
BEFREE |
However, both the allele G of SNP rs12610286 (P = 0.029; OR 2.411; CI 1.134-5.123) and one major haplotype (TTGTGA; P = 0.012; OR 2.749; CI 1.223-6.174) were found significantly more frequent in patients with SPS type I in comparison with controls.
|
23168074 |
2012 |
|
rs12610286
|
GP6;LOC107985325
|
Stiff-Person Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
However, both the allele G of SNP rs12610286 (P = 0.029; OR 2.411; CI 1.134-5.123) and one major haplotype (TTGTGA; P = 0.012; OR 2.749; CI 1.223-6.174) were found significantly more frequent in patients with SPS type I in comparison with controls.
|
23168074 |
2012 |
|
rs1671153
|
GP6;LOC107985325
|
SMALL PATELLA SYNDROME
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a higher occurrence of three SNPs of the GP6 gene in SPS patients versus control subjects (rs1671153: 0.204 vs. 0.048, odds ratio [OR] 5.116, 95% confidence interval [CI] 1.536-17.03; rs1654419: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149-9.619; rs1613662: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149-9.619).
|
22901851 |
2012 |
|
rs1671153
|
GP6;LOC107985325
|
Stiff-Person Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a higher occurrence of three SNPs of the GP6 gene in SPS patients versus control subjects (rs1671153: 0.204 vs. 0.048, odds ratio [OR] 5.116, 95% confidence interval [CI] 1.536-17.03; rs1654419: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149-9.619; rs1613662: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149-9.619).
|
22901851 |
2012 |