PDE4A, phosphodiesterase 4A, 5141

N. diseases: 168; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1051738
rs1051738
Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0033860
Disease:
Psoriasis 		0.700 GeneticVariation GWASCAT Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. 25574825 2015
dbSNP: rs7256672
rs7256672
Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0020445
Disease:
Hypercholesterolemia, Familial 		0.700 GeneticVariation GWASDB Low-density lipoprotein receptor mutations generate synthetic genome-wide associations. 22968135 2013
dbSNP: rs553040076
rs553040076
Entrez Id: 5141;11140
Gene Symbol: PDE4A;CDC37
PDE4A;CDC37
CUI: C0344315
Disease:
Depressed mood 		0.010 GeneticVariation BEFREE Q31L mutants had lower PDE4B activity, consistent with their resistance to rolipram, suggesting decreased PDE4 activity as a contributory factor in depression. 17481393 2007
dbSNP: rs553040076
rs553040076
Entrez Id: 5141;11140
Gene Symbol: PDE4A;CDC37
PDE4A;CDC37
CUI: C0011570
Disease:
Mental Depression 		0.010 GeneticVariation BEFREE Q31L mutants had lower PDE4B activity, consistent with their resistance to rolipram, suggesting decreased PDE4 activity as a contributory factor in depression. 17481393 2007
dbSNP: rs553040076
rs553040076
Entrez Id: 5141;11140
Gene Symbol: PDE4A;CDC37
PDE4A;CDC37
CUI: C0011581
Disease:
Depressive disorder 		0.010 GeneticVariation BEFREE Q31L mutants had lower PDE4B activity, consistent with their resistance to rolipram, suggesting decreased PDE4 activity as a contributory factor in depression. 17481393 2007