SERPINE2, serpin family E member 2, 5270

N. diseases: 87; N. variants: 12
Disease: Chronic Obstructive Airway Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs16865421
rs16865421
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.020 GeneticVariation BEFREE Polymorphisms of rs16865421-AG carried by the Uygur population may be protective against COPD. 31215134 2019
dbSNP: rs729631
rs729631
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.020 GeneticVariation BEFREE Two SNPs (rs729631 and rs975278), which are in strong linkage disequilibrium (LD) and locate in block 1 on the LD map of our samples, showed significant association both with the risk of COPD and decline in baseline lung function after Bonferroni correction (P < 0.05). 21611750 2012
dbSNP: rs16865421
rs16865421
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.020 GeneticVariation BEFREE In haplotype analysis, the GACC haplotype carrying the polymorphic allele at the rs16865421 was associated with a significantly decreased risk of COPD when compared to the AACC haplotype (adjusted OR=0.58, 95% CI=0.38-0.89, P=0.01), and this effect was evident in younger individuals (adjusted OR=0.30, 95% CI=0.14-0.64, P=0.002). 19949669 2009
dbSNP: rs729631
rs729631
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.020 GeneticVariation BEFREE To test this hypothesis, the association of four SERPINE2 single nucleotide polymorphisms (SNPs; rs16865421A>G, rs7583463A>C, rs729631C>G, and rs6734100C>G) with the risk of COPD was investigated in a case-control study of 311 COPD patients and 386 controls. 19949669 2009
dbSNP: rs3795879
rs3795879
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.010 GeneticVariation BEFREE The results suggest that the rs3795879 polymorphism of SERPINE2 is not a risk factor for COPD. 26214473 2015
dbSNP: rs975278
rs975278
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.010 GeneticVariation BEFREE Two SNPs (rs729631 and rs975278), which are in strong linkage disequilibrium (LD) and locate in block 1 on the LD map of our samples, showed significant association both with the risk of COPD and decline in baseline lung function after Bonferroni correction (P < 0.05). 21611750 2012
dbSNP: rs6734100
rs6734100
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.010 GeneticVariation BEFREE To test this hypothesis, the association of four SERPINE2 single nucleotide polymorphisms (SNPs; rs16865421A>G, rs7583463A>C, rs729631C>G, and rs6734100C>G) with the risk of COPD was investigated in a case-control study of 311 COPD patients and 386 controls. 19949669 2009