SEMA5B, semaphorin 5B, 54437

N. diseases: 22; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0018801
Disease:
Heart failure 		0.700 GeneticVariation GWASCAT Specifically, from Group 2, we find rs7632505 on 3q21.1 in <i>SEMA5B</i>, rs460976 on 21q22.3 (1 kb from <i>TMPRSS2</i>) and rs12420422 on 11q24.1 predominantly associated with a variety of CVDs, rs4905014 in <i>ITPK1</i> associated with stroke and heart failure, rs7081476 on 10p12.1 in <i>ANKRD26</i> associated with multiple diseases including DM, CVDs, and NDs. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0038454
Disease:
Cerebrovascular accident 		0.700 GeneticVariation GWASCAT Our follow-up analyses show that rs7632505, rs4905014, and rs8082812 have age-dependent effects on coronary heart disease or stroke. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0010068
Disease:
Coronary heart disease 		0.700 GeneticVariation GWASCAT Our follow-up analyses show that rs7632505, rs4905014, and rs8082812 have age-dependent effects on coronary heart disease or stroke. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0337438
Disease:
Glucose measurement 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0011849
Disease:
Diabetes Mellitus 		0.700 GeneticVariation GWASCAT Specifically, from Group 2, we find rs7632505 on 3q21.1 in <i>SEMA5B</i>, rs460976 on 21q22.3 (1 kb from <i>TMPRSS2</i>) and rs12420422 on 11q24.1 predominantly associated with a variety of CVDs, rs4905014 in <i>ITPK1</i> associated with stroke and heart failure, rs7081476 on 10p12.1 in <i>ANKRD26</i> associated with multiple diseases including DM, CVDs, and NDs. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0018935
Disease:
Hematocrit procedure 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0495706
Disease:
elevated blood glucose level 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0006826
Disease:
Malignant Neoplasms 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0004238
Disease:
Atrial Fibrillation 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0011847
Disease:
Diabetes 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0428883
Disease:
Diastolic blood pressure 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs9868873
rs9868873
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0014859
Disease:
Esophageal Neoplasms 		G 0.700 GeneticVariation GWASCAT Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993 2011
dbSNP: rs9868873
rs9868873
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		G 0.700 GeneticVariation GWASDB Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993 2011
dbSNP: rs148102705
rs148102705
Entrez Id: 54437;112268448
Gene Symbol: SEMA5B;LOC112268448
SEMA5B;LOC112268448
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.700 GeneticVariation UNIPROT
dbSNP: rs7632505
rs7632505
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
CUI: C0040021
Disease:
Thromboangiitis Obliterans 		0.010 GeneticVariation BEFREE However, after genomic control correction for population stratification only three of these SNPS were highly significantly associated with TAO: rs376511 in IL17RC (OR = 24.4, 95% CI:8.68 - 68.62, p < 0.0001), rs7632505 in SEMA5B (OR = 29.47, 95% CI:7.16 - 121.3, p < 0.0001), and rs10178082 (OR = 18.09, 95% CI: 6.56 - 49.92, p < 0.0001) showed a significant risk of TAO in the Uyghur population. 26829209 2016