TOLLIP, toll interacting protein, 54472

N. diseases: 40; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5743899
rs5743899
Entrez Id: 54472;105376512
Gene Symbol: TOLLIP;LOC105376512
TOLLIP;LOC105376512
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE For TOLLIP, rs5743899 (p = 0.005, OR = 1.83, 95% CI: 1.20-2.80) CC genotype were risk factors for PTB progression. 29924447 2018
dbSNP: rs3750920
rs3750920
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE Furthermore, in a case-population study in Vietnam with 760 cord blood samples and 671 TB case patients, we found that SNPs rs3750920 and rs5743899 were associated with susceptibility to tuberculosis (p = 7.03 × 10(-16) and 6.97 × 10(-7), respectively). 22778396 2012
dbSNP: rs5743899
rs5743899
Entrez Id: 54472;105376512
Gene Symbol: TOLLIP;LOC105376512
TOLLIP;LOC105376512
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE Furthermore, in a case-population study in Vietnam with 760 cord blood samples and 671 TB case patients, we found that SNPs rs3750920 and rs5743899 were associated with susceptibility to tuberculosis (p = 7.03 × 10(-16) and 6.97 × 10(-7), respectively). 22778396 2012
dbSNP: rs5743890
rs5743890
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
A 0.830 GeneticVariation GWASCAT Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. 24429156 2013
dbSNP: rs5743890
rs5743890
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
A 0.830 GeneticVariation GWASDB Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. 24429156 2013
dbSNP: rs5743894
rs5743894
Entrez Id: 54472;105376512
Gene Symbol: TOLLIP;LOC105376512
TOLLIP;LOC105376512
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
G 0.800 GeneticVariation GWASDB Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. 24429156 2013
dbSNP: rs5743894
rs5743894
Entrez Id: 54472;105376512
Gene Symbol: TOLLIP;LOC105376512
TOLLIP;LOC105376512
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
G 0.800 GeneticVariation GWASCAT Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. 24429156 2013
dbSNP: rs111521887
rs111521887
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
G 0.700 GeneticVariation GWASDB Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. 24429156 2013
dbSNP: rs3168046
rs3168046
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0206062
Disease:
Lung Diseases, Interstitial
A 0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. 23583980 2013
dbSNP: rs3750920
rs3750920
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0206062
Disease:
Lung Diseases, Interstitial
C 0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. 23583980 2013
dbSNP: rs3793964
rs3793964
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0206062
Disease:
Lung Diseases, Interstitial
T 0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. 23583980 2013
dbSNP: rs3829223
rs3829223
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0206062
Disease:
Lung Diseases, Interstitial
C 0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. 23583980 2013
dbSNP: rs5744034
rs5744034
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0206062
Disease:
Lung Diseases, Interstitial
A 0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. 23583980 2013
dbSNP: rs3793964
rs3793964
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0023343
Disease:
Leprosy
0.010 GeneticVariation BEFREE In a case-control gene-association study with 477 cases and 1021 controls in Nepal, TOLLIP single-nucleotide polymorphism rs3793964 TT genotype was associated with increased susceptibility to leprosy (recessive, P = 1.4 × 10(-3)) and with increased skin expression of TOLLIP and IL-1Ra. 26610735 2016
dbSNP: rs5743890
rs5743890
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
0.830 GeneticVariation BEFREE Individuals who developed IPF despite having the protective TOLLIP minor allele of rs5743890 carried an increased mortality risk (meta-analysis with fixed-effect model: hazard ratio 1·72 [95% CI 1·24-2·38]; p=0·0012). 24429156 2013
dbSNP: rs3750920
rs3750920
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0023348
Disease:
Leprosy, Lepromatous
0.010 GeneticVariation BEFREE Just the individuals with genotype C/C of rs3750920 have a trend of protective effect to developing LL. 24294608 2013
dbSNP: rs5743890
rs5743890
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
0.830 GeneticVariation BEFREE Leukocyte telomere length (LTL), <i>MUC5B</i> rs35705950 and <i>TOLLIP</i> rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF).In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival and rate of disease progression in patients with interstitial pneumonia with autoimmune features (IPAF, n=250) and connective tissue disease-associated interstitial lung disease (CTD-ILD, n=248). 30635297 2019
dbSNP: rs5743890
rs5743890
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0009782
Disease:
Connective Tissue Diseases
0.010 GeneticVariation BEFREE Leukocyte telomere length (LTL), <i>MUC5B</i> rs35705950 and <i>TOLLIP</i> rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF).In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival and rate of disease progression in patients with interstitial pneumonia with autoimmune features (IPAF, n=250) and connective tissue disease-associated interstitial lung disease (CTD-ILD, n=248). 30635297 2019
dbSNP: rs5743890
rs5743890
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0206061
Disease:
Pneumonia, Interstitial
0.010 GeneticVariation BEFREE Leukocyte telomere length (LTL), <i>MUC5B</i> rs35705950 and <i>TOLLIP</i> rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF).In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival and rate of disease progression in patients with interstitial pneumonia with autoimmune features (IPAF, n=250) and connective tissue disease-associated interstitial lung disease (CTD-ILD, n=248). 30635297 2019
dbSNP: rs3793964
rs3793964
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. 24935372 2014
dbSNP: rs3793964
rs3793964
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. 24935372 2014
dbSNP: rs5743867
rs5743867
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE Moreover, rs5743867 under addictive (p = 0.005, OR = 1.54, 95% CI: 1.14-2.07) and recessive model (p = 0.004, OR = 1.86, 95% CI: 1.22-2.83) were also risk factors for PTB susceptibility. 29924447 2018
dbSNP: rs3750920
rs3750920
Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C1800706
Disease:
Idiopathic Pulmonary Fibrosis
0.010 GeneticVariation BEFREE NAC may be an efficacious therapy for individuals with IPF with an rs3750920 (TOLLIP) TT genotype, but it was associated with a trend toward harm in those with a CC genotype. 26331942 2015
dbSNP: rs5743899
rs5743899
Entrez Id: 54472;105376512
Gene Symbol: TOLLIP;LOC105376512
TOLLIP;LOC105376512
CUI: C0276447
Disease:
Rhinovirus infection
0.010 GeneticVariation BEFREE Our data suggest that Tollip SNP rs5743899 may predict varying airway response to RV infection in asthma. 27513438 2016
dbSNP: rs5743899
rs5743899
Entrez Id: 54472;105376512
Gene Symbol: TOLLIP;LOC105376512
TOLLIP;LOC105376512
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE Our data suggest that Tollip SNP rs5743899 may predict varying airway response to RV infection in asthma. 27513438 2016