TMEM106B, transmembrane protein 106B, 54664

N. diseases: 126; N. variants: 13
Disease: Frontotemporal dementia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7791726
rs7791726
Entrez Id: 54664
Gene Symbol: TMEM106B
TMEM106B
CUI: C0338451
Disease:
Frontotemporal dementia 		G 0.700 GeneticVariation GWASCAT Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. 29724592 2018
dbSNP: rs3173615
rs3173615
Entrez Id: 54664
Gene Symbol: TMEM106B
TMEM106B
CUI: C0338451
Disease:
Frontotemporal dementia 		0.030 GeneticVariation BEFREE Recent studies found that two polymorphisms (rs363371 and rs363324) in VMAT2 might be a risk factor for Parkinson's disease (PD) in Caucasians, while the two other variants (rs1990622 and rs3173615) in TMEM106B increased the risk for frontotemporal dementia (FTD). 28477711 2017
dbSNP: rs3173615
rs3173615
Entrez Id: 54664
Gene Symbol: TMEM106B
TMEM106B
CUI: C0338451
Disease:
Frontotemporal dementia 		0.030 GeneticVariation BEFREE The major allele of SNP rs3173615 is a risk factor in sporadic FTD, whereas the minor allele seems protective in GRN- and C9orf72-mediated FTD. 28888721 2017
dbSNP: rs3173615
rs3173615
Entrez Id: 54664
Gene Symbol: TMEM106B
TMEM106B
CUI: C0338451
Disease:
Frontotemporal dementia 		0.030 GeneticVariation BEFREE TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia. 23742080 2013