CASZ1, castor zinc finger 1, 54897

N. diseases: 132; N. variants: 15
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11121615
rs11121615
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0042345
Disease:
Varicosity 		0.710 GeneticVariation BEFREE This study demonstrates that the CASZ1 gene associated C-allele of rs11121615 has a significant, reproducible, association with CVD (CEAP C ≥ 2 meta-odds ratio 1.31, 95% CI 1.27-1.34, P = 1 × 10<sup>-98</sup>, PHet = 0.25), but not with non-varicose vein (CEAP C1, telangiectasia or reticular veins) forms of venous disease. 31570750 2019
dbSNP: rs11121615
rs11121615
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0042345
Disease:
Varicosity 		T 0.710 GeneticVariation GWASCAT Varicose veins of lower extremities: Insights from the first large-scale genetic study. 30998689 2019
dbSNP: rs11121615
rs11121615
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0042345
Disease:
Varicosity 		T 0.710 GeneticVariation GWASCAT Clinical and Genetic Determinants of Varicose Veins. 30566020 2018
dbSNP: rs880315
rs880315
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0038454
Disease:
Cerebrovascular accident 		0.710 GeneticVariation GWASCAT Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 29531354 2018
dbSNP: rs880315
rs880315
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0038454
Disease:
Cerebrovascular accident 		0.710 GeneticVariation BEFREE Two other SNPs, rs880315 and rs11072518, showed a trend towards association with stroke risk, but did not reach statistical significance. 28682427 2017
dbSNP: rs10157038
rs10157038
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0042834
Disease:
Vital capacity 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12046278
rs12046278
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0020538
Disease:
Hypertensive disease 		C 0.700 GeneticVariation GWASCAT The known hypertension locus, CASZ1, was a top finding among EAs (P = 1.1 × 10-8) and in the race-combined analysis (P = 1.5 × 10-9) using the normotensive control group (rs12046278, odds ratio = 0.71 (95% confidence interval: 0.6-0.8)). 31545351 2019
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs284262
rs284262
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs284316
rs284316
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0017654
Disease:
Glomerular Filtration Rate 		C 0.700 GeneticVariation GWASCAT Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis. 31015462 2019
dbSNP: rs284316
rs284316
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs34071855
rs34071855
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0730345
Disease:
Microalbuminuria 		G 0.700 GeneticVariation GWASCAT Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 31511532 2019
dbSNP: rs544722
rs544722
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C1305855
Disease:
Body mass index 		T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs59985166
rs59985166
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C1821417
Disease:
RESTING HEART RATE 		0.700 GeneticVariation GWASCAT Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis. 30940143 2019
dbSNP: rs59985166
rs59985166
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.700 GeneticVariation GWASCAT Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis. 30940143 2019
dbSNP: rs74748843
rs74748843
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs880315
rs880315
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C1306620
Disease:
Systolic blood pressure measurement 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C1305849
Disease:
Diastolic blood pressure measurement 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0428883
Disease:
Diastolic blood pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0428886
Disease:
Mean blood pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17035646
rs17035646
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0001948
Disease:
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs284277
rs284277
Entrez Id: 54897
Gene Symbol: CASZ1
CASZ1
CUI: C0004238
Disease:
Atrial Fibrillation 		C 0.700 GeneticVariation GWASCAT Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018