Disease: Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519946
rs1057519946
Entrez Id: 5518
Gene Symbol: PPP2R1A
PPP2R1A
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE Taken together, our results demonstrate that the R183W mutation in PP2A Aα scaffold abrogates the tumor suppressive actions of PP2A, thereby potentiating oncogenic signaling and reducing drug sensitivity of RAS-mutant cells. 31541192 2020
dbSNP: rs786205228
rs786205228
Entrez Id: 5518
Gene Symbol: PPP2R1A
PPP2R1A
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE Restoration of wild-type PPP2R1A in P179R-mutant endometrial cancer cells increases phosphatase activity and inhibits tumor growth <i>in vivo</i> Furthermore, a small-molecule activator of PP2A (SMAP) phenocopies restoration of wild-type PPP2R1A to suppress tumor growth. 31416848 2019