|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation |
BEFREE |
In the first set, although rs4919510:C>G was unrelated to breast cancer in general patients, variant genotypes (CG/GG) were specifically associated with increased risk of HER2-positive subtype (Adjusted OR = 1.97, 95% CI, 1.34-2.90 in the recessive model).
|
22586447 |
2012 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation |
BEFREE |
In the first set, although rs4919510:C>G was unrelated to breast cancer in general patients, variant genotypes (CG/GG) were specifically associated with increased risk of HER2-positive subtype (Adjusted OR = 1.97, 95% CI, 1.34-2.90 in the recessive model).
|
22586447 |
2012 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
HER2-positive carcinoma of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes.
|
22586447 |
2012 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Colorectal Carcinoma
|
|
0.050 |
GeneticVariation |
BEFREE |
There was no significant association between rs4919510 and colorectal cancer risk (African American: OR(GG vs. CC) 0.89 [95% CI, 0.41-1.80]) (Caucasian: OR(GG vs. CC) 1.76, ([95% CI, 0.48-6.39]).
|
22606253 |
2012 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation |
BEFREE |
There was no significant association between rs4919510 and colorectal cancer risk (African American: OR(GG vs. CC) 0.89 [95% CI, 0.41-1.80]) (Caucasian: OR(GG vs. CC) 1.76, ([95% CI, 0.48-6.39]).
|
22606253 |
2012 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings reveal rs4919510C > G in miR-608 as a simple marker to predict LRR in patients with radiotherapy-treated nasopharyngeal carcinoma.
|
23796562 |
2013 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Locally Recurrent Malignant Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings reveal rs4919510C > G in miR-608 as a simple marker to predict LRR</span> in patients with radiotherapy-treated nasopharyngeal carcinoma.
|
23796562 |
2013 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Septicemia
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that the rs4919510G/C SNP in hsa-mir-608 may be a prognostic biomarker for sepsis in patients with major trauma.
|
24743625 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that the rs4919510G/C SNP in hsa-mir-608 may be a prognostic biomarker for sepsis in patients with major trauma.
|
24743625 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Septicemia
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 9 selected SNPs with potential functional significance, only 1 (miR-608 rs4919510) was found to be strongly associated with a higher risk of developing sepsis and multiple organ dysfunction in all 3 independent study cohorts.
|
24743625 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 9 selected SNPs with potential functional significance, only 1 (miR-608 rs4919510) was found to be strongly associated with a higher risk of developing sepsis and multiple organ dysfunction in all 3 independent study cohorts.
|
24743625 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Liver carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
However, no significant association between miRNA‑608 rs4919510 and the risk of HCC/HBV‑associated HCC was found.
|
25190221 |
2014 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Ovarian Failure, Premature
|
|
0.010 |
GeneticVariation |
BEFREE |
Four breast cancer-related microRNA polymorphisms (miR-27aA > G [rs895819], miR-135bC > T [rs74141216], miR-423C > A [rs6505162], and miR-608G > C [rs4919510]) were genotyped in 136 women with idiopathic POI and 224 controls of Korean ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis.
|
25203895 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
After further stratification for tumor grading, stage III patients carrying the G allele of rs4919510 and undergoing adjuvant chemotherapy were at decreased risk of relapse (HR = 0.44; 95% CI: 0.20-0.94; adjusted P = 0.03).
|
25368035 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Papillary thyroid carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
Three SNPs (rs67106263 in mir-3144, GA versus GG, OR = 1.35, 1.09-1.68; rs4919510 in mir-608, CC versus GG/GC, OR = 0.76, 0.60-0.97; and rs79402775 in mir-933, AA versus GG/GA, OR = 1.76, 1.00-3.12) were associated with PTC risk.
|
25381599 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Benign neoplasm of thyroid gland
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, three SNPs (rs10061133 in mir-449b, rs79402775 in mir-933 and rs4919510 in mir-608) showed at least borderline correlations with the risk of BN.
|
25381599 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, the rs4919510C>G adverse genotypes significantly interacted with Epstein-Barr virus (EBV) infection on increasing NPC risk (P=0.001).
|
25861865 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Epstein-Barr Virus Infections
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the rs4919510C>G adverse genotypes significantly interacted with Epstein-Barr virus (EBV) infection on increasing NPC risk (P=0.001).
|
25861865 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Carcinoma of lung
|
|
0.050 |
GeneticVariation |
BEFREE |
The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively).
|
26083623 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Primary malignant neoplasm of lung
|
|
0.050 |
GeneticVariation |
BEFREE |
The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively).
|
26083623 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Malignant neoplasm of lung
|
|
0.050 |
GeneticVariation |
BEFREE |
The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively).
|
26083623 |
2015 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Liver carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our results illustrated the potential role of miR-608 rs4919510 as a prognostic marker for HCC patients undergoing surgical resection of the tumor.
|
26815502 |
2016 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
Further stratification analysis indicated that rs4919510 was significantly associated with OS in patients who were satisfied with one of the following criteria: male gender, HbsAg-positive, α-fetoprotein (AFP)-positive, tumor size >5 cm, cirrhosis, solitary tumor, I + II pTNM stage, or no tumor capsule.
|
26815502 |
2016 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, a significantly higher frequency of rs4919510 CC genotype was observed in patients with cirrhosis (22.9 %, 55/240) than those without cirrhosis (14.0 %, 17/121) (P = 0.047).
|
26815502 |
2016 |
|
rs4919510
|
SEMA4G;MRPL43;MIR608
|
Cirrhosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, a significantly higher frequency of rs4919510 CC genotype was observed in patients with cirrhosis (22.9 %, 55/240) than those without cirrhosis (14.0 %, 17/121) (P = 0.047).
|
26815502 |
2016 |