The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p = 4.1 × 10<sup>-3</sup>), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p = 3.47 × 10<sup>-3</sup>), and eight SNPs associated with total cholesterol (top SNP rs1012049 with p = 6.09 × 10<sup>-3</sup>).
One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p = 4.1 × 10<sup>-3</sup>), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p = 3.47 × 10<sup>-3</sup>), and eight SNPs associated with total cholesterol (top SNP rs1012049 with p = 6.09 × 10<sup>-3</sup>).
One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p = 4.1 × 10<sup>-3</sup>), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p = 3.47 × 10<sup>-3</sup>), and eight SNPs associated with total cholesterol (top SNP rs1012049 with p = 6.09 × 10<sup>-3</sup>).
One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p = 4.1 × 10<sup>-3</sup>), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p = 3.47 × 10<sup>-3</sup>), and eight SNPs associated with total cholesterol (top SNP rs1012049 with p = 6.09 × 10<sup>-3</sup>).
One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p = 4.1 × 10<sup>-3</sup>), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p = 3.47 × 10<sup>-3</sup>), and eight SNPs associated with total cholesterol (top SNP rs1012049 with p = 6.09 × 10<sup>-3</sup>).
One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p = 4.1 × 10<sup>-3</sup>), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p = 3.47 × 10<sup>-3</sup>), and eight SNPs associated with total cholesterol (top SNP rs1012049 with p = 6.09 × 10<sup>-3</sup>).
Although these SNPs were not associated with type 1 diabetes overall (p > 0.001), the SNP most associated with AAD, rs72975913, was associated with susceptibility to type 1 diabetes in those individuals diagnosed at less than 5 years old (p = 2.3 × 10<sup>-9</sup>).
The aim of this work was to evaluate the expression levels of these two genes in duodenal mucosa of active and treated CD patients and in controls, and to determine whether SNPs (rs802734, rs55743914, rs72975916, rs10484718 and rs9491896) associated with CD have any influence on gene expression.
The aim of this work was to evaluate the expression levels of these two genes in duodenal mucosa of active and treated CD patients and in controls, and to determine whether SNPs (rs802734, rs55743914, rs72975916, rs10484718 and rs9491896) associated with CD have any influence on gene expression.