RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs836474
rs836474
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0004352
Disease:
Autistic Disorder 		0.700 GeneticVariation GWASDB Individual common variants exert weak effects on the risk for autism spectrum disorders. 22843504 2012
dbSNP: rs836489
rs836489
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0751676
Disease:
Basal Cell Cancer 		G 0.700 GeneticVariation GWASCAT Combined analysis of keratinocyte cancers identifies novel genome-wide loci. 31174203 2019
dbSNP: rs836489
rs836489
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0007117
Disease:
Basal cell carcinoma 		G 0.700 GeneticVariation GWASCAT Combined analysis of keratinocyte cancers identifies novel genome-wide loci. 31174203 2019
dbSNP: rs836489
rs836489
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0206710
Disease:
Basal Cell Neoplasm 		G 0.700 GeneticVariation GWASCAT Combined analysis of keratinocyte cancers identifies novel genome-wide loci. 31174203 2019
dbSNP: rs35589149
rs35589149
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs7784465
rs7784465
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C1305855
Disease:
Body mass index 		T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs1057519874
rs1057519874
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0596263
Disease:
Carcinogenesis 		0.020 GeneticVariation BEFREE Impact of point mutation P29S in RAC1 on tumorigenesis. 27699663 2016
dbSNP: rs1057519874
rs1057519874
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0596263
Disease:
Carcinogenesis 		0.020 GeneticVariation BEFREE Rac1 P29S mutant is known to strongly promote oncogenesis by facilitating its intrinsic GDP dissociation and thereby increasing the level of the GTP-bound state. 30891502 2019
dbSNP: rs12536544
rs12536544
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0684249
Disease:
Carcinoma of lung 		0.010 GeneticVariation BEFREE RAC1 rs836554, rs4720672, and rs12536544 polymorphisms may be novel and useful genetic markers to predict the toxicity induced by platinum-based chemotherapy in lung cancer patients. 27299748 2016
dbSNP: rs10951982
rs10951982
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C2316810
Disease:
Chronic kidney disease stage 5 		0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219 2016
dbSNP: rs6954996
rs6954996
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C2316810
Disease:
Chronic kidney disease stage 5 		0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219 2016
dbSNP: rs702483
rs702483
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C2316810
Disease:
Chronic kidney disease stage 5 		0.010 GeneticVariation BEFREE In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05). 26841219 2016
dbSNP: rs836488
rs836488
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C2316810
Disease:
Chronic kidney disease stage 5 		0.010 GeneticVariation BEFREE In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05). 26841219 2016
dbSNP: rs9374
rs9374
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C2316810
Disease:
Chronic kidney disease stage 5 		0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219 2016
dbSNP: rs1057519874
rs1057519874
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0151779
Disease:
Cutaneous Melanoma 		T 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519874
rs1057519874
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0151779
Disease:
Cutaneous Melanoma 		A 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519874
rs1057519874
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0151779
Disease:
Cutaneous Melanoma 		0.710 GeneticVariation BEFREE Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma. 25043693 2014
dbSNP: rs1057519948
rs1057519948
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0151779
Disease:
Cutaneous Melanoma 		T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs10951982
rs10951982
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.020 GeneticVariation BEFREE Children with IBD treated with thiopurines were prospectively followed for 1 year and were genotyped for 3 Rac1 SNPs previously found to be relevant to IBD: rs10951982, rs4720672, and rs34932801. 25885881 2015
dbSNP: rs10951982
rs10951982
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.020 GeneticVariation BEFREE Patients with inflammatory bowel disease who had the rs10951982 risk allele had increased expression of RAC1 compared to those without this allele. 21684284 2011
dbSNP: rs10951982
rs10951982
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219 2016
dbSNP: rs6954996
rs6954996
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219 2016
dbSNP: rs702483
rs702483
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.010 GeneticVariation BEFREE In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05). 26841219 2016
dbSNP: rs836488
rs836488
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.010 GeneticVariation BEFREE In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05). 26841219 2016
dbSNP: rs9374
rs9374
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219 2016