RAD51C, RAD51 paralog C, 5889

N. diseases: 162; N. variants: 96
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057517641
rs1057517641
Entrez Id: 5889;56155
Gene Symbol: RAD51C;TEX14
RAD51C;TEX14
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 		G 0.700 GeneticVariation CLINVAR
dbSNP: rs1057517641
rs1057517641
Entrez Id: 5889;56155
Gene Symbol: RAD51C;TEX14
RAD51C;TEX14
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		G 0.700 GeneticVariation CLINVAR
dbSNP: rs1057519355
rs1057519355
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 		T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs1060502588
rs1060502588
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		G 0.700 CausalMutation CLINVAR
dbSNP: rs1060502601
rs1060502601
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		A 0.700 CausalMutation CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728 2016
dbSNP: rs1060502601
rs1060502601
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0677776
Disease:
Hereditary Breast and Ovarian Cancer Syndrome 		A 0.700 GeneticVariation CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251 2015
dbSNP: rs1060502601
rs1060502601
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		A 0.700 CausalMutation CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251 2015
dbSNP: rs1060502601
rs1060502601
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 		A 0.700 CausalMutation CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728 2016
dbSNP: rs1060502601
rs1060502601
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 		A 0.700 CausalMutation CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251 2015
dbSNP: rs1060502601
rs1060502601
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR
dbSNP: rs1060502605
rs1060502605
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		C 0.700 CausalMutation CLINVAR
dbSNP: rs1060502605
rs1060502605
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		CCAAT 0.700 CausalMutation CLINVAR
dbSNP: rs1064792966
rs1064792966
Entrez Id: 5889;105371843
Gene Symbol: RAD51C;LOC105371843
RAD51C;LOC105371843
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		C 0.700 GeneticVariation CLINVAR Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. 12966089 2003
dbSNP: rs1302297709
rs1302297709
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE The novel variant E233G in RAD51D is more highly represented in high-risk, site-specific, familial breast cancer cases that are not associated with the BRCA1/2 genes, with a frequency of 5.74% (n = 174) compared to a control population (n = 567) and another subset of breast cancer patients (n = 765) with a prevalence of around 2% only (comparison to controls, OR = 2.6, 95% CI 1.12-6.03; p < 0.021). 15170666 2004
dbSNP: rs1302297709
rs1302297709
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE The novel variant E233G in RAD51D is more highly represented in high-risk, site-specific, familial breast cancer cases that are not associated with the BRCA1/2 genes, with a frequency of 5.74% (n = 174) compared to a control population (n = 567) and another subset of breast cancer patients (n = 765) with a prevalence of around 2% only (comparison to controls, OR = 2.6, 95% CI 1.12-6.03; p < 0.021). 15170666 2004
dbSNP: rs1302297709
rs1302297709
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0346153
Disease:
Breast Cancer, Familial 		0.010 GeneticVariation BEFREE This suggests a role for E233G as a low-penetrance susceptibility gene in the specific subgroup of high-risk familial breast cancer cases that are not related to BRCA1/2. 15170666 2004
dbSNP: rs1327086366
rs1327086366
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		A 0.700 GeneticVariation CLINVAR Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan. 24800917 2014
dbSNP: rs1327086366
rs1327086366
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		A 0.700 GeneticVariation CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
dbSNP: rs1327086366
rs1327086366
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0677776
Disease:
Hereditary Breast and Ovarian Cancer Syndrome 		A 0.700 GeneticVariation CLINVAR Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. 29922827 2018
dbSNP: rs1327086366
rs1327086366
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		A 0.700 GeneticVariation CLINVAR Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. 21990120 2012
dbSNP: rs1327086366
rs1327086366
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 GeneticVariation CLINVAR
dbSNP: rs1413872299
rs1413872299
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 		C 0.700 CausalMutation CLINVAR
dbSNP: rs1413872299
rs1413872299
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251 2015
dbSNP: rs145310733
rs145310733
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		G 0.700 GeneticVariation CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
dbSNP: rs145310733
rs145310733
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O 		G 0.700 GeneticVariation CLINVAR Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan. 24800917 2014